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A severe case of systemic lupus erythematosus with increased pressure communicating hydrocephalus
Journal article   Open access   Peer reviewed

A severe case of systemic lupus erythematosus with increased pressure communicating hydrocephalus

Gülşen Özen, Sibel Yılmaz-Öner, Neşe Tuncer, Türkay Akbaş, Serhan Tuğlular and Haner Direskeneli
European journal of rheumatology, Vol.2(2), pp.76-77
06/01/2015
DOI: 10.5152/eurjrheum.2015.0084
PMCID: PMC5047267
PMID: 27708931
url
https://doi.org/10.5152/eurjrheum.2015.0084View
Published (Version of record) Open Access

Abstract

Normal/increased pressure hydrocephaly is an unusual manifestation of systemic lupus erythematosus (SLE), and the pathogenesis is still unclear. We report the case of an 18-year-old white female with severe refractory renal and pulmonary involvement who developed stupor during intensive immunosuppressive treatment. Enlarged ventricles on imaging and increased intracranial pressure with the exclusion of infectious and hemorrhagic/thrombotic processes suggested increased pressure communicating hydrocephalus associated with SLE. Few case reports are reviewed, and potential pathophysiologic mechanisms are discussed.
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