A shell-based inverse approach of stress analysis in intracranial aneurysms

Jia Lu; Shouhua Hu; Madhavan L Raghavan

doi:10.1007/s10439-013-0751-4

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A shell-based inverse approach of stress analysis in intracranial aneurysms

Journal article

Peer reviewed

A shell-based inverse approach of stress analysis in intracranial aneurysms

Jia Lu, Shouhua Hu and Madhavan L Raghavan

Annals of biomedical engineering, Vol.41(7), pp.1505-1515

07/2013

DOI: 10.1007/s10439-013-0751-4

PMCID: PMC3679309

PMID: 23392863

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Abstract

Predicting pressure induced wall stress in intracranial aneurysms continues to be of interest for aneurysm safety assessment. In quasi-static analysis, there are two distinct approaches that one may take, the forward approach and the inverse approach. The inverse approach starts from a deformed configuration and thus is naturally suited to image-based, patient-specific analysis. Early studies by the authors' team suggested that the inverse approach, in the context of estimating the wall stress in cerebral aneurysms, depends weakly on the material description. In this article, we present a population study to further demonstrate the inverse method, in particular, the remarkable feature of insensitivity to material properties. Twenty-six aneurysm models derived from patient-specific images were employed in the study. Wall stresses were predicted in both the inverse and forward approaches using three material models. Results showed that, while forward computation yielded up to ~100% stress difference between some materials, the inverse solutions stayed close across materials. The inverse method, in addition to being methodologically accurate in dealing with pre-deformations, has the added convenience of insensitivity to uncertainties in wall tissue properties. New insight into the stress-geometry relation was also discussed.

Angiography

Finite Element Analysis

Intracranial Aneurysm - diagnostic imaging

Models, Biological

Arteries - physiopathology

Humans

Stress, Mechanical

Arteries - pathology

Intracranial Aneurysm - pathology

Intracranial Aneurysm - physiopathology

Pressure

Details

Title: Subtitle: A shell-based inverse approach of stress analysis in intracranial aneurysms
Creators: Jia Lu - Department of Mechanical and Industrial Engineering, The University of Iowa, Iowa City, IA 52242, USA. jialu@engineering.uiowa.edu
Shouhua Hu
Madhavan L Raghavan
Resource Type: Journal article
Publication Details: Annals of biomedical engineering, Vol.41(7), pp.1505-1515
DOI: 10.1007/s10439-013-0751-4
PMID: 23392863
PMCID: PMC3679309
NLM abbreviation: Ann Biomed Eng
ISSN: 0090-6964
eISSN: 1573-9686
Publisher: United States
Grant note: R01 HL083475 / NHLBI NIH HHS 1R01HL083475 / NHLBI NIH HHS
Language: English
Date published: 07/2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Mechanical Engineering
Record Identifier: 9984064246702771

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