Journal article
A startling role for synaptic zinc
Neuron (Cambridge, Mass.), Vol.52(4), pp.572-4
11/22/2006
DOI: 10.1016/j.neuron.2006.11.007
PMID: 17114041
Abstract
It has long been known that the synaptic vesicles of certain glutamatergic terminals, as well as some inhibitory terminals, are richly supplied with zinc ions, yet the functional role of this pool of zinc in synaptic transmission has remained elusive. In this issue of Neuron, Hirzel et al. provide direct in vivo evidence that endogenous zinc is required for proper functioning of neuronal circuitry in the brainstem and spinal cord. They show that knockin mice carrying a point mutation which eliminates zinc potentiation of alpha1-containing glycine receptors develop severe sensorimotor deficits characteristic of impaired glycinergic neurotransmission.
Details
- Title: Subtitle
- A startling role for synaptic zinc
- Creators
- Alan Kay - Department of BiologyJacques Neyton - Laboratoire de Neurobiologie (UMR 8544)Pierre Paoletti - Laboratoire de Neurobiologie (UMR 8544)
- Contributors
- Jacques Neyton (Editor)
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.52(4), pp.572-4
- Publisher
- Elsevier
- DOI
- 10.1016/j.neuron.2006.11.007
- PMID
- 17114041
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Language
- English
- Date published
- 11/22/2006
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9983991958402771
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