A structured review of baculovirus infection process: integration of mathematical models and biomolecular information on cell-virus interaction

Abha Saxena; Prasanna Kumar Byram; Suraj Kumar Singh; Jayanta Chakraborty; David Murhammer; Lopamudra Giri

doi:10.1099/jgv.0.001108

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A structured review of baculovirus infection process: integration of mathematical models and biomolecular information on cell-virus interaction

Journal article

Open access

Peer reviewed

A structured review of baculovirus infection process: integration of mathematical models and biomolecular information on cell-virus interaction

Abha Saxena, Prasanna Kumar Byram, Suraj Kumar Singh, Jayanta Chakraborty, David Murhammer and Lopamudra Giri

Journal of general virology, Vol.99(9), pp.1151-1171

09/2018

DOI: 10.1099/jgv.0.001108

PMID: 30027883

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Abstract

The baculovirus expression vector system (BEVS) is an emerging tool for the production of recombinant proteins, vaccines and bio-pesticides. However, a system-level understanding of the complex infection process is important in realizing large-scale production at a lower cost. The entire baculovirus infection process is summarized as a combination of various modules and the existing mathematical models are discussed in light of these modules. This covers a systematic review of the present understanding of virus internalization, viral DNA replication, protein expression, budded virus (BV) and occlusion-derived virus (ODV) formation, few polyhedral (FP) and defective interfering particle (DIP) mutant formation, cell cycle modification and apoptosis during the viral infection process. The corresponding theoretical models are also included. Current knowledge regarding the molecular biology of the baculovirus/insect cell system is integrated with population balance and mass action kinetics models. Furthermore, the key steps for simulating cell and virus densities and their underlying features are discussed. This review may facilitate the further development and refinement of mathematical models, thereby providing the basis for enhanced control and optimization of bioreactor operation.

Apoptosis

Cell Cycle

Mathematical Models

DIPs

baculovirus infection

polyhedra

Details

Title: Subtitle: A structured review of baculovirus infection process: integration of mathematical models and biomolecular information on cell-virus interaction
Creators: Abha Saxena - Indian Institute of Technology Hyderabad
Prasanna Kumar Byram - Indian Institute of Technology Hyderabad
Suraj Kumar Singh - Indian Institute of Technology Hyderabad
Jayanta Chakraborty - Indian Institute of Technology Kharagpur
David Murhammer - University of Iowa
Lopamudra Giri - Indian Institute of Technology Hyderabad
Resource Type: Journal article
Publication Details: Journal of general virology, Vol.99(9), pp.1151-1171
DOI: 10.1099/jgv.0.001108
PMID: 30027883
NLM abbreviation: J Gen Virol
ISSN: 0022-1317
eISSN: 1465-2099
Language: English
Date published: 09/2018
Academic Unit: Chemical and Biochemical Engineering
Record Identifier: 9984197246702771

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