Journal article
A summary of the measured pK values of the ionizable groups in folded proteins
Protein science, Vol.18(1), pp.247-251
01/01/2009
DOI: 10.1002/pro.19
PMCID: PMC2708032
PMID: 19177368
Abstract
We tabulated 541 measured pK values reported in the literature for the Asp, Glu, His, Cys, Tyr, and Lys side chains, and the C and N termini of 78 folded proteins. The majority of these values are for the Asp, Glu, and His side chains. The average pK values are Asp 3.5 +/- 1.2 (139); Glu 4.2 +/- 0.9 (153); His 6.6 +/- 1.0 (131); Cys 6.8 +/- 2.7 (25); Tyr 10.3 +/- 1.2 (20); Lys 10.5 +/- 1.1 (35); C-terminus 3.3 +/- 0.8 (22) and N-terminus 7.7 +/- 0.5 (16). We compare these results with the measured pK values of these groups in alanine pentapeptides, and comment on our overall findings.
Details
- Title: Subtitle
- A summary of the measured pK values of the ionizable groups in folded proteins
- Creators
- Gerald R. Grimsley - Texas A&M University SystemJ. Martin Scholtz - Texas A&M UniversityC. Nick Pace - Texas A&M University
- Resource Type
- Journal article
- Publication Details
- Protein science, Vol.18(1), pp.247-251
- DOI
- 10.1002/pro.19
- PMID
- 19177368
- PMCID
- PMC2708032
- NLM abbreviation
- Protein Sci
- ISSN
- 0961-8368
- eISSN
- 1469-896X
- Publisher
- Wiley
- Number of pages
- 5
- Grant note
- GM 37039; GM 52483 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA BE-1060; BE-1281 / Welch Foundation; The Welch Foundation Tom and Jean McMullin Professorship R01GM037039 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Language
- English
- Date published
- 01/01/2009
- Academic Unit
- Research Administration; Pharmaceutical Sciences and Experimental Therapeutics; Biochemistry and Molecular Biology; Chemistry
- Record Identifier
- 9984293073202771
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