Journal article
A synthesis of highly substituted aromatics through regiocontrolled construction of cyclobutenones bearing unsaturated substituents at the 4-position
Journal of the American Chemical Society, Vol.114(4), pp.1412-1418
02/01/1992
DOI: 10.1021/ja00030a043
Abstract
2,3-Substituted 4-chloro-2-cyclobutenones, prepared by regiospecific transformations of substituted cyclobutenediones, undergo palladium-catalyzed cross-coupling with vinyl- and arylstannanes and vinylzirconium reagents to form 4-Runsat-2-cyclobutenones. On thermolysis (100 °C), these substrates transform into substituted phenols in high yield. A pentasubstituted aromatic and a variety of tri- and tetrasubstituted aromatic compounds were prepared in a regiospecific fashion using this chemistry. © 1992, American Chemical Society. All rights reserved.
Details
- Title: Subtitle
- A synthesis of highly substituted aromatics through regiocontrolled construction of cyclobutenones bearing unsaturated substituents at the 4-position
- Creators
- Damian J KrysanAngela GurskiLanny S Liebeskind
- Resource Type
- Journal article
- Publication Details
- Journal of the American Chemical Society, Vol.114(4), pp.1412-1418
- Publisher
- American Chemical Society
- DOI
- 10.1021/ja00030a043
- ISSN
- 0002-7863
- eISSN
- 1520-5126
- Language
- English
- Date published
- 02/01/1992
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984297323402771
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