Journal article
A synthesis of strychnine by a longest linear sequence of six steps
Chemical science (Cambridge), Vol.2(4), pp.649-651
2011
DOI: 10.1039/c1sc00009h
Abstract
Strychnine is synthesized via a longest linear sequence of six steps from commercially available starting materials. Key steps include a base-mediated intramolecular Diels–Alder reaction of a tryptamine-derived Zincke aldehyde, a Ru-catalyzed trans-hydrosilylation of 1,4-butynediol, and a tandem Brook rearrangement/intramolecular conjugate addition reaction that affords the Wieland–Gumlich aldehyde.
Details
- Title: Subtitle
- A synthesis of strychnine by a longest linear sequence of six steps
- Creators
- David B. C MartinChristopher D Vanderwal
- Resource Type
- Journal article
- Publication Details
- Chemical science (Cambridge), Vol.2(4), pp.649-651
- DOI
- 10.1039/c1sc00009h
- ISSN
- 2041-6520
- eISSN
- 2041-6539
- Language
- English
- Date published
- 2011
- Academic Unit
- Iowa Neuroscience Institute; Chemistry
- Record Identifier
- 9984065856202771
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