Journal article
A systematic review and meta-analysis of the association between vitamin A intake, serum vitamin A, and risk of liver cancer
Nutrition and health (Berkhamsted), Vol.24(2), pp.121-131
06/2018
DOI: 10.1177/0260106018777170
PMID: 29792083
Abstract
Background: Previous evidence supports that vitamin A decreases the risk of several types of cancer. However, the association between vitamin A and liver cancer is inconclusive.
Aim: This systematic review and meta-analysis summarizes the existing literature, discussing the association between vitamin A intake, serum vitamin A, and liver cancer in adult populations.
Methods: A systematic literature review was performed by searching the EMBASE, PubMed, Scopus and International Pharmaceutical Abstract databases using terms related to vitamin A (e.g. retinol, α-carotene, β-carotene, and β-cryptoxanthin) and hepatic cancer without applying any time restriction. A meta-analysis was performed using random effect models.
Results: The meta-analysis of five studies showed no association between serum retinol and liver cancer (pooled risk ratio = 1.90 (0.40-9.02); n = 5 studies, I2 = 92%). In addition, the systematic review of studies from 1955 to July 2017 found studies that indicated no association between the intake and serum level of α-carotene ( n = 2) and β-cryptoxanthin ( n = 1) and the risk of liver cancer. Further, the associations between retinol intake ( n = 3), β-carotene intake ( n = 3), or serum β-carotene ( n = 3) and liver cancer were inconclusive.
Conclusions: Current information on the association between vitamin A intake and liver cancer or serum vitamin A and liver cancer are limited. Most studies demonstrated no association between dietary vitamin A and the risk of liver cancer. However, the finding was based on a small number of studies with potential publication bias. Therefore, large observational studies should be conducted to confirm these associations.
Keywords: Vitamin a; beta carotene; carotenoids; liver cancer; liver neoplasms; retinol.
Details
- Title: Subtitle
- A systematic review and meta-analysis of the association between vitamin A intake, serum vitamin A, and risk of liver cancer
- Creators
- Nattawut Leelakanok - Faculty of Pharmaceutical Sciences, Burapha University, Chonburi, ThailandRonilda R D’Cunha - College of Pharmacy, University of Iowa, USAGrerk Sutamtewagul - Carver College of Medicine, University of Iowa, USAMarin L Schweizer - Carver College of Medicine, University of Iowa, USA, College of Public Health, University of Iowa, USA, Department of Veterans Affairs Health Care System, Iowa City, USA
- Resource Type
- Journal article
- Publication Details
- Nutrition and health (Berkhamsted), Vol.24(2), pp.121-131
- DOI
- 10.1177/0260106018777170
- PMID
- 29792083
- ISSN
- 0260-1060
- eISSN
- 2047-945X
- Language
- English
- Date published
- 06/2018
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984094395002771
Metrics
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