Journal article
A systematic review and meta-analysis of hormone receptor expression in low-grade serous ovarian carcinoma
European journal of obstetrics & gynecology and reproductive biology, Vol.256, pp.172-178
01/01/2021
DOI: 10.1016/j.ejogrb.2020.11.021
PMID: 33246201
Abstract
Serous ovarian carcinoma is the most common histological type of ovarian cancer, with high-grade serous ovarian carcinoma (HGSOC) being more common than low-grade serous ovarian carcinoma (LGSOC). Despite pathogenic and clinical differences, both grades of serous ovarian carcinoma share the propensity to express receptors for the female hormones – oestrogen (ERs) and progesterone receptors (PRs) – albeit in differing frequencies.
Systematic review and meta-analysis of studies reporting the expression of hormone receptors in LGSOC, and comparison with expression in HGSOC.
Expression of ERs is observed in 80.7 % of patients with LGSOC [95 % confidence interval (CI) 72.2–89.1 %] and 61.5 % of patients with HGSOC (95 % CI 38.8–84.1 %). Expression of PRs is observed in 54.4 % of patients with LGSOC (95 % CI 44.3–64.4 %) and 30.7 % of patients with HGSOC (95 % CI 15.7–45.7 %).
A higher percentage of LGSOCs are positive for ER expression compared with HGSOCs. Similarly, a higher percentage of LGSOCs are positive for PR expression, although PR expression is lower than ER expression. Expression of hormone receptors may represent a therapeutic opportunity for treatment with agents that block their activity, especially in LGSOC which is less responsive to chemotherapy and therapeutic options are limited.
Details
- Title: Subtitle
- A systematic review and meta-analysis of hormone receptor expression in low-grade serous ovarian carcinoma
- Creators
- Ioannis A. Voutsadakis - Sault Area Hospital
- Resource Type
- Journal article
- Publication Details
- European journal of obstetrics & gynecology and reproductive biology, Vol.256, pp.172-178
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.ejogrb.2020.11.021
- PMID
- 33246201
- ISSN
- 0301-2115
- eISSN
- 1872-7654
- Number of pages
- 7
- Language
- English
- Date published
- 01/01/2021
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806608002771
Metrics
4 Record Views