Journal article
A systematic review of the epidemiology of carbapenem-resistant Enterobacteriaceae in the United States
Antimicrobial resistance and infection control, Vol.7(1), pp.55-55
2018
DOI: 10.1186/s13756-018-0346-9
PMCID: PMC5926528
PMID: 29719718
Abstract
Carbapenem-resistant Enterobacteriaceae (CRE) pose an urgent public health threat in the United States. An important step in planning and monitoring a national response to CRE is understanding its epidemiology and associated outcomes. We conducted a systematic literature review of studies that investigated incidence and outcomes of CRE infection in the US. We performed searches in MEDLINE via Ovid, CDSR, DARE, CENTRAL, NHS EED, Scopus, and Web of Science for articles published from 1/1/2000 to 2/1/2016 about the incidence and outcomes of CRE at US sites. Five studies evaluated incidence, but many used differing definitions for cases. Across the entire US population, the reported incidence of CRE was 0.3-2.93 infections per 100,000 person-years. Infection rates were highest in long-term acute-care (LTAC) hospitals. There was insufficient data to assess trends in infection rates over time. Four studies evaluated outcomes. Mortality was higher in CRE patients in some but not all studies. While the incidence of CRE infections in the United States remains low on a national level, the incidence is highest in LTACs. Studies assessing outcomes in CRE-infected patients are limited in number, small in size, and have reached conflicting results. Future research should measure a variety of clinical outcomes and adequately adjust for confounders to better assess the full burden of CRE.
Details
- Title: Subtitle
- A systematic review of the epidemiology of carbapenem-resistant Enterobacteriaceae in the United States
- Creators
- Daniel J Livorsi - 2Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, USAMargaret L Chorazy - 3University of Iowa College of Public Health, Iowa City, USAMarin L Schweizer - 2Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, USAErin C Balkenende - 1Center for Comprehensive Access Delivery & Research, Iowa City VA Health Care System, Iowa City, USAAmy E Blevins - 5Ruth Lilly Medical Library, Indiana University School of Medicine, Indianapolis, Indiana USARajeshwari Nair - 2Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, USAMatthew H Samore - 7Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah USARichard E Nelson - 7Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah USAKarim Khader - 7Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah USAEli N Perencevich - 2Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, USA
- Resource Type
- Journal article
- Publication Details
- Antimicrobial resistance and infection control, Vol.7(1), pp.55-55
- DOI
- 10.1186/s13756-018-0346-9
- PMID
- 29719718
- PMCID
- PMC5926528
- NLM abbreviation
- Antimicrob Resist Infect Control
- ISSN
- 2047-2994
- eISSN
- 2047-2994
- Publisher
- England
- Grant note
- name: Safe Healthcare, Epidemiology, and Prevention Research Development (SHEPheRD) Program, award: 200-2011-42039
- Language
- English
- Date published
- 2018
- Academic Unit
- Public Health Administration; Epidemiology; Internal Medicine
- Record Identifier
- 9983779496802771
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