A test of a linear model of glaucomatous structure-function loss reveals sources of variability in retinal nerve fiber and visual field measurements

Donald C Hood; Susan C Anderson; Michael Wall; Ali S Raza; Randy H Kardon

doi:10.1167/iovs.08-2697

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A test of a linear model of glaucomatous structure-function loss reveals sources of variability in retinal nerve fiber and visual field measurements

Journal article

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A test of a linear model of glaucomatous structure-function loss reveals sources of variability in retinal nerve fiber and visual field measurements

Donald C Hood, Susan C Anderson, Michael Wall, Ali S Raza and Randy H Kardon

Investigative ophthalmology & visual science, Vol.50(9), pp.4254-4266

09/2009

DOI: 10.1167/iovs.08-2697

PMCID: PMC3003847

PMID: 19443710

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https://www.ncbi.nlm.nih.gov/pmc/articles/3003847View

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Abstract

Retinal nerve fiber (RNFL) thickness and visual field loss data from patients with glaucoma were analyzed in the context of a model, to better understand individual variation in structure versus function. Optical coherence tomography (OCT) RNFL thickness and standard automated perimetry (SAP) visual field loss were measured in the arcuate regions of one eye of 140 patients with glaucoma and 82 normal control subjects. An estimate of within-individual (measurement) error was obtained by repeat measures made on different days within a short period in 34 patients and 22 control subjects. A linear model, previously shown to describe the general characteristics of the structure-function data, was extended to predict the variability in the data. For normal control subjects, between-individual error (individual differences) accounted for 87% and 71% of the total variance in OCT and SAP measures, respectively. SAP within-individual error increased and then decreased with increased SAP loss, whereas OCT error remained constant. The linear model with variability (LMV) described much of the variability in the data. However, 12.5% of the patients' points fell outside the 95% boundary. An examination of these points revealed factors that can contribute to the overall variability in the data. These factors include epiretinal membranes, edema, individual variation in field-to-disc mapping, and the location of blood vessels and degree to which they are included by the RNFL algorithm. The model and the partitioning of within- versus between-individual variability helped elucidate the factors contributing to the considerable variability in the structure-versus-function data.

Nerve Fibers - pathology

Intraocular Pressure

Tomography, Optical Coherence

Humans

Middle Aged

Optic Nerve Diseases - diagnosis

Ophthalmoscopy

Linear Models

Glaucoma - diagnosis

Retinal Ganglion Cells - pathology

Young Adult

Algorithms

Visual Fields

Aged, 80 and over

Adult

Aged

Visual Field Tests

Details

Title: Subtitle: A test of a linear model of glaucomatous structure-function loss reveals sources of variability in retinal nerve fiber and visual field measurements
Creators: Donald C Hood - Department of Psychology, Columbia University, New York, New York 10027, USA. dch3@columbia.edu
Susan C Anderson
Michael Wall
Ali S Raza
Randy H Kardon
Resource Type: Journal article
Publication Details: Investigative ophthalmology & visual science, Vol.50(9), pp.4254-4266
DOI: 10.1167/iovs.08-2697
PMID: 19443710
PMCID: PMC3003847
NLM abbreviation: Invest Ophthalmol Vis Sci
ISSN: 0146-0404
eISSN: 1552-5783
Publisher: United States
Grant note: R01-EY-02115 / NEI NIH HHS R01 EY002115 / NEI NIH HHS R01-EY-09076 / NEI NIH HHS R01 EY002115-32 / NEI NIH HHS R01 EY009076 / NEI NIH HHS
Language: English
Date published: 09/2009
Academic Unit: Neurology; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983979964002771

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