Journal article
A time course investigation of vitamin A level and lipid composition of the liver endoplasmic reticulum in rats following treatment with congeneric polychlorobiphenyls
Toxicology (Amsterdam), Vol.60(3), pp.253-261
1990
DOI: 10.1016/0300-483X(90)90148-A
PMID: 2107605
Abstract
The drug metabolizing enzyme activities, the vitamin A content and the fatty acid composition in the endoplasmic reticulum membrane were studied in rat liver after a single injection of the polychlorobiphenyls (PCBs) 3,3′,4,4′-tetrachlorobiphenyl [(3,4)
2Cl] or 2,2′,4,4′,5,5′-hexachlorobiphenyl [(2,4,5)
2Cl], 300 μ mol/kg each. The microsomal vitamin A level was markedly lowered 3 days after treatment with (3,4)
2Cl, a coplanar type inducer of cytochrome
P-450. A marked increase in microsomal AHH and UDPGT activities occurred within 3 days after injection of (3,4)
2Cl whereas (2,4,5,)
2Cl treatment enhanced APDM activity only. Arachidonic, stearic and linoleic acid microsomal contents were enhanced by the two congeners. (3,4)
2Cl caused the proportion of docosahexaenoic acid to decrease. No highly significant correlation was found between the vitamin A content and lipid components in the microsomal membrane. However, the vitamin A level was inversely related to the activities of drug metabolizing enzymes induced by coplanar compounds (cytochrome
P-450 towards benzo[a]pyrene and UDP glucuronosyl transferase towards 4-nitrophenol).
Details
- Title: Subtitle
- A time course investigation of vitamin A level and lipid composition of the liver endoplasmic reticulum in rats following treatment with congeneric polychlorobiphenyls
- Creators
- Jean-François Narbonne - Laboratoire de Toxicologie Alimentaire, Université de Bordeaux I, avenue des Facultés, 33405 Talence Cedex, FrancePascal Grolier - Laboratoire de Toxicologie Alimentaire, Université de Bordeaux I, avenue des Facultés, 33405 Talence Cedex, FranceRobert Albrecht - Laboratoire de Biologie du CNAM, 292 Rue Saint-Martin, 75141 Paris, FranceVéronique Azais - Laboratoire des Sciences de la Consommation, INRA-CNRZ 78350 Jouy-en-Josas, FranceFranz Oesch - Institut für Toxikologie der Universität Mainz Obere Zahlbacher Str. 67 6500 Mainz, F.R.GLarry W Robertson - Institut für Toxikologie der Universität Mainz Obere Zahlbacher Str. 67 6500 Mainz, F.R.G
- Resource Type
- Journal article
- Publication Details
- Toxicology (Amsterdam), Vol.60(3), pp.253-261
- Publisher
- Elsevier Ireland Ltd
- DOI
- 10.1016/0300-483X(90)90148-A
- PMID
- 2107605
- ISSN
- 0300-483X
- eISSN
- 1879-3185
- Language
- English
- Date published
- 1990
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984002443002771
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