Journal article
A time for promiscuity in a eukaryotic recombinase
The Journal of biological chemistry, Vol.292(26), pp.11136-11137
06/30/2017
DOI: 10.1074/jbc.H117.787614
PMCID: PMC5491794
PMID: 28667173
Abstract
The exchange of DNA strands between broken and intact molecules lies at the heart of fundamental cellular processes ranging from repairing DNA damage by homologous recombination to generation of genetic diversity during sexual reproduction. New work by Lee and colleagues utilizes the DNA curtain method, an elegant single-molecule technique, to demonstrate common and idiosyncratic features in the DNA strand exchange mechanisms of three RecA-family recombinases, bacterial RecA, and eukaryotic Rad51 and Dmc1 proteins.
Details
- Title: Subtitle
- A time for promiscuity in a eukaryotic recombinase
- Creators
- Maria Spies - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- The Journal of biological chemistry, Vol.292(26), pp.11136-11137
- DOI
- 10.1074/jbc.H117.787614
- PMID
- 28667173
- PMCID
- PMC5491794
- NLM abbreviation
- J Biol Chem
- ISSN
- 0021-9258
- eISSN
- 1083-351X
- Publisher
- Amer Soc Biochemistry Molecular Biology Inc
- Number of pages
- 2
- Grant note
- R01 GM108617 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01GM108617 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Language
- English
- Date published
- 06/30/2017
- Academic Unit
- Radiation Oncology; Biochemistry and Molecular Biology
- Record Identifier
- 9984288724402771
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