Journal article
A transdiagnostic network for psychiatric illness derived from atrophy and lesions
Nature human behaviour, Vol.7(3), pp.420-429
03/2023
DOI: 10.1038/s41562-022-01501-9
PMCID: PMC10236501
PMID: 36635585
Abstract
Psychiatric disorders share neurobiology and frequently co-occur. This neurobiological and clinical overlap highlights opportunities for transdiagnostic treatments. In this study, we used coordinate and lesion network mapping to test for a shared brain network across psychiatric disorders. In our meta-analysis of 193 studies, atrophy coordinates across six psychiatric disorders mapped to a common brain network defined by positive connectivity to anterior cingulate and insula, and by negative connectivity to posterior parietal and lateral occipital cortex. This network was robust to leave-one-diagnosis-out cross-validation and specific to atrophy coordinates from psychiatric versus neurodegenerative disorders (72 studies). In 194 patients with penetrating head trauma, lesion damage to this network correlated with the number of post-lesion psychiatric diagnoses. Neurosurgical ablation targets for psychiatric illness (four targets) also aligned with the network. This convergent brain network for psychiatric illness may partially explain high rates of psychiatric comorbidity and could highlight neuromodulation targets for patients with more than one psychiatric disorder.
Details
- Title: Subtitle
- A transdiagnostic network for psychiatric illness derived from atrophy and lesions
- Creators
- Joseph J Taylor - Brigham and Women's HospitalChristopher Lin - Brigham and Women's HospitalDaniel Talmasov - Columbia University Irving Medical CenterMichael A Ferguson - Brigham and Women's HospitalFrederic L W V J Schaper - Brigham and Women's HospitalJing Jiang - University of IowaMadeleine Goodkind - University of New MexicoJordan Grafman - Northwestern UniversityAmit Etkin - Stanford UniversityShan H Siddiqi - Brigham and Women's HospitalMichael D Fox - Brigham and Women's Hospital
- Resource Type
- Journal article
- Publication Details
- Nature human behaviour, Vol.7(3), pp.420-429
- DOI
- 10.1038/s41562-022-01501-9
- PMID
- 36635585
- PMCID
- PMC10236501
- NLM abbreviation
- Nat Hum Behav
- ISSN
- 2397-3374
- eISSN
- 2397-3374
- Grant note
- R21MH126271 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH113929 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) K23MH121657 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) 31081 / Brain and Behavior Research Foundation (Brain & Behavior Research Foundation) R56AG069086 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) 846534 / American Epilepsy Society (AES) R01AG060987 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) 29441 / Brain and Behavior Research Foundation (Brain & Behavior Research Foundation) R01MH115949 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) NIMH R21MH126271 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) I01 CX002293 / CSRD VA K23MH129829 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
- Language
- English
- Electronic publication date
- 01/12/2023
- Date published
- 03/2023
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984360007002771
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