Journal article
A trip to the ER: coping with stress
Trends in cell biology, Vol.14(1), pp.20-28
2004
DOI: 10.1016/j.tcb.2003.11.001
PMID: 14729177
Abstract
The accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER) induces a coordinated adaptive program called the unfolded protein response (UPR). The UPR alleviates stress by upregulating protein folding and degradation pathways in the ER and inhibiting protein synthesis. With a basic conceptual framework for the UPR, including the identification of key mediators of the response, now in place, recent work has turned towards investigating how the response is regulated and how its effects radiate beyond the immediate realm of protein secretion. This review highlights advances in these areas and attempts to forecast important issues that must be addressed soon.
Details
- Title: Subtitle
- A trip to the ER: coping with stress
- Creators
- D.Thomas RutkowskiRandal J Kaufman
- Resource Type
- Journal article
- Publication Details
- Trends in cell biology, Vol.14(1), pp.20-28
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.tcb.2003.11.001
- PMID
- 14729177
- ISSN
- 0962-8924
- eISSN
- 1879-3088
- Language
- English
- Date published
- 2004
- Academic Unit
- Anatomy and Cell Biology; Internal Medicine
- Record Identifier
- 9984094649502771
Metrics
31 Record Views