Journal article
A tumultuous transition to motherhood: Altered brain and hormonal responses in mothers with postpartum depression
Journal of neuroendocrinology, Vol.31(9), pp.e12794-n/a
09/2019
DOI: 10.1111/jne.12794
PMID: 31520440
Abstract
Postpartum depression (PPD) is a common but complex condition that is poorly understood and multifactorial in aetiology. It is a condition that can compromise the mother's care for her infant, which may pose challenges to the formation of the mother-infant bond and the infant's overall development. Past research has looked at abnormalities in the brain circuitry and hormonal profiles of mothers with PPD compared to non-depressed mothers. However, abnormalities in PPD that may specifically affect the mother's care of her infant have not been clearly assessed. Thus, the present review aims to synthesise studies of altered brain and hormonal responses in mothers with PPD in relation to their care of their infant. First, we review maternal brain responses and their relation to PPD symptomatology, focusing on the salience/fear network, reward/attachment network and default mode network. Next, we discuss oxytocin and hypothalamic-pituitary-adrenal axis hormones in the context of maternal behaviour and PPD. Finally, we synthesise these findings and propose how future studies may benefit from the combined study of both neural and hormonal activity to better understand the underlying neurobiology of maternal care in PPD.
Details
- Title: Subtitle
- A tumultuous transition to motherhood: Altered brain and hormonal responses in mothers with postpartum depression
- Creators
- Amanda J Nguyen - School of Medicine, Baylor College of Medicine, Houston, TX, USAElisabeth Hoyer - School of Medicine, Baylor College of Medicine, Houston, TX, USAPurva Rajhans - Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, USALane Strathearn - Center for Disabilities and Development, University of Iowa Stead Family Children's Hospital, Iowa City, IA, USASohye Kim - Center for Reproductive Psychiatry, Pavilion for Women, Texas Children's Hospital, Houston, TX, USA
- Resource Type
- Journal article
- Publication Details
- Journal of neuroendocrinology, Vol.31(9), pp.e12794-n/a
- Publisher
- United States
- DOI
- 10.1111/jne.12794
- PMID
- 31520440
- ISSN
- 0953-8194
- eISSN
- 1365-2826
- Language
- English
- Date published
- 09/2019
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Developmental and Behavioral Pediatrics; Neuroscience and Pharmacology
- Record Identifier
- 9984070208202771
Metrics
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