Journal article
A user-friendly Hypercard interface for human linkage analysis
Computer applications in the biosciences, Vol.9(6), pp.757-759
12/1993
DOI: 10.1093/bioinformatics/9.6.757
PMID: 8143163
Abstract
The availability of a large number of highly informative genetic markers has made human linkage analysis faster and easier to perform. However, current linkage analysis software does not provide an organizational database into which a large body of linkage data can be easily stored and manipulated. This manual entry and editing of linkage data is often time consuming and prone to typing errors. In addition, the large number of alleles in many of these markers must be reduced in order to perform linkage analysis with multiple loci across large genetic distances. This reduction in allele number is often difficult and confusing, especially in large pedigrees. We have taken advantage of the Macintosh-based Hypercard program to develop an interface with which linkage data can be easily stored, retrieved and edited. For each family, the components of the pedigree, including ID numbers, sex and affection status, only need to be entered once. The program (Linkage Interface) retrieves this information each time the data from a new polymorphic marker is entered. Linkage Interface has flexible editing capabilities that allow the user to change any portion of the pedigree, including the addition or deletion of family members, without affecting previously entered genotype data. Linkage Interface can also analyze both the pedigree and marker data and will detect any inconsistencies in inheritance patterns. In addition, the program can reduce the number of alleles for a polymorphic marker. Linkage Interface will then compare the 'reduced' data to the original marker data and assists in maintaining all informative meioses by pointing out which meioses have become non-informative.
Details
- Title: Subtitle
- A user-friendly Hypercard interface for human linkage analysis
- Creators
- B E Nichols - Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City 52242V C SheffieldE M Stone
- Resource Type
- Journal article
- Publication Details
- Computer applications in the biosciences, Vol.9(6), pp.757-759
- DOI
- 10.1093/bioinformatics/9.6.757
- PMID
- 8143163
- NLM abbreviation
- Comput Appl Biosci
- ISSN
- 0266-7061
- eISSN
- 1460-2059
- Publisher
- England
- Grant note
- HG00457 / NHGRI NIH HHS P30HD27748 / NICHD NIH HHS EY08426 / NEI NIH HHS
- Language
- English
- Date published
- 12/1993
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Medical Genetics and Genomics; Ophthalmology and Visual Sciences
- Record Identifier
- 9983979951202771
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