Journal article
AAEM minimonograph #46: Neurogenic muscle hypertrophy
Muscle & nerve, Vol.19(7), pp.811-818
07/1996
DOI: 10.1002/(SICI)1097-4598(199607)19:7<811::AID-MUS1>3.0.CO;2-C
PMID: 8965832
Abstract
Muscle hypertrophy occurs uncommonly in several neurogenic disorders including neuropathies, radiculopathies, spinal muscular atrophy, and post‐polio syndrome. Its pathogenesis varies in different circumstances. In the presence of generalized myokymia and neuromyotonia (Isaacs' syndrome), symmetrical hypertrophy appears to be the result of continuous spontaneous electrical stimulation of myofibers and, in some cases, results in type 1 myofiber preponderance. Focal hypertrophy occurring with radiculopathies and mononeuropathies was associated with complex repetitive discharges (CRDs) in approximately half the cases. CRDs may play a role in the pathogenesis of myofiber hypertrophy by continuous myofiber stimulation, but in some cases, with and without CRDs, myofiber hypertrophy may be related to mechanical events. Muscle enlargement seen in old polio appears to involve a significant degree of pseudohypertrophy, although some myofiber hypertrophy occurs. The symmetrical occurrence of hypertrophy in genetically determined disorders, such as spinal muscular atrophy, and hereditary motor and sensory neuropathy types 1 and 2 may have both a genetic and a mechanical basis in addition to pseudohypertrophy in some cases. © 1996 American Association of Electrodiagnostic Medicine. Published by John Wiley & Sons, Inc.
Details
- Title: Subtitle
- AAEM minimonograph #46: Neurogenic muscle hypertrophy
- Creators
- Ludwig Gutmann
- Resource Type
- Journal article
- Publication Details
- Muscle & nerve, Vol.19(7), pp.811-818
- Publisher
- John Wiley & Sons, Inc; New York
- DOI
- 10.1002/(SICI)1097-4598(199607)19:7<811::AID-MUS1>3.0.CO;2-C
- PMID
- 8965832
- ISSN
- 0148-639X
- eISSN
- 1097-4598
- Number of pages
- 8
- Language
- English
- Date published
- 07/1996
- Academic Unit
- Neurology
- Record Identifier
- 9984020780102771
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