Journal article
ACUTE CARDIOPULMONARY EFFECTS OF A DUAL-ENDOTHELIN RECEPTOR ANTAGONIST ON OLEIC ACID-INDUCED PULMONARY ARTERIAL HYPERTENSION IN DOGS
Experimental lung research, Vol.30(1), pp.31-42
2004
DOI: 10.1080/01902140490252821
PMID: 14967602
Abstract
The objective of this study was to evaluate the cardiopulmonary effects of a dual-endothelin (ET) receptor antagonist, Tezosentan, on oleic acid (OA)-induced acute lung injury with pulmonary arterial hypertension in dogs. Twelve pentobarbital-anesthetized dogs with intravenous OA-induced acute lung injury (ALI) were divided into 2 groups. The control group (n = 6) received saline treatment, whereas the treatment group (n = 6) received the ET receptor antagonist, Tezosentan (1 mg/kg intravenous [IV] + 1 mg/kg/h IV infusion). Cardiopulmonary parameters were monitored continuously for 1 hour. OA administration resulted in a significant increase in mean pulmonary arterial pressure (MPAP) and pulmonary vascular resistance (PVR) and a decrease in mean systemic arterial pressure (MSAP), systemic vascular resistance (SVR), and cardiac output (CO) in all dogs. Tezosentan treatment markedly attenuated the pulmonary hypertension, with a 32% decrease in MPAP (from 23±2 mm Hg to 15±2 mm Hg; P < .01) and a 22% decrease in PVR (from 860±105 dyn · s · cm−5to 670±96 dyn · s · cm−5; P < .01) at the end of study. MSAP and SVR were unchanged after Tezosentan treatment, and there was an increase in cardiac output and a decline in peak inspiratory pressure (PIP) in the Tezosentan group compared with the control group. These results indicate that the dual-ET receptor antagonist, Tezosentan, can attenuate the pulmonary hypertension induced by OA. Thus, dual-ET receptor antagonists such as Tezosentan may be useful in the management of acute pulmonary arterial hypertension, complicating the course of OA-induced lung injury.
Details
- Title: Subtitle
- ACUTE CARDIOPULMONARY EFFECTS OF A DUAL-ENDOTHELIN RECEPTOR ANTAGONIST ON OLEIC ACID-INDUCED PULMONARY ARTERIAL HYPERTENSION IN DOGS
- Creators
- Ling Wang - Fudan UniversityDu Ming Zhu - Fudan UniversityXiao Su - Fudan UniversityChun Xue Bai - Fudan UniversityLorraine B. Ware - Vanderbilt UniversityMichael A. Matthay - University of California, San Francisco
- Resource Type
- Journal article
- Publication Details
- Experimental lung research, Vol.30(1), pp.31-42
- Publisher
- Informa UK Ltd
- DOI
- 10.1080/01902140490252821
- PMID
- 14967602
- ISSN
- 0190-2148
- eISSN
- 1521-0499
- Language
- English
- Date published
- 2004
- Academic Unit
- Orthopedics and Rehabilitation
- Record Identifier
- 9984304645902771
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