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AFP-producing hepatoid adenocarcinoma of the stomach: a case report
Journal article   Peer reviewed

AFP-producing hepatoid adenocarcinoma of the stomach: a case report

Panagiotis J Vlachostergios, Ioannis A Voutsadakis, Sotirios Barbanis, Foteini Karasavvidou and Christos N Papandreou
Cases journal, Vol.2(12), pp.9296-9296
12/09/2009
DOI: 10.1186/1757-1626-2-9296
PMCID: PMC2803960
PMID: 20062620

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Abstract

Hepatoid gastric adenocarcinoma is a distinct variant of gastric carcinoma which represents a comparatively small percentage of the disease and in many cases is producing high serum alpha-fetoprotein (AFP). We report a case of an 85 year old woman who presented with epigastric and right upper quadrant pain and was found in a CT scan to have multiple liver nodules and a gastric antrum mass as well as an elevated AFP level of 155000 IU/ml. An endoscopic biopsy of the antral mass showed hepatoid variant of gastric adenocarcinoma. The patient refused any further treatment and died 4 months after diagnosis. Hepatoid gastric adenocarcinoma is considered to have a poor prognosis, although cases with survival of several years have been reported. Poor outcome in most of the cases is due to the fact that, as in our patient, metastatic disease is already present at diagnosis.
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