Journal article
AGXT2: a promiscuous aminotransferase
Trends in pharmacological sciences (Regular ed.), Vol.35(11), pp.31-38
11/01/2014
DOI: 10.1016/j.tips.2014.09.005
PMCID: PMC4254113
PMID: 25294000
Abstract
Alanine-glyoxylate aminotransferase 2 (AGXT2) is a multifunctional mitochondrial aminotransferase that was first identified in 1978. The physiological importance of AGXT2 was largely overlooked for three decades because AGXT2 is less active in glyoxylate metabolism than AGXT1, the enzyme that is deficient in primary hyperoxaluria type I. Recently, several novel functions of AGXT2 have been 'rediscovered' in the setting of modern genomic and metabolomic studies. It is now apparent that AGXT2 has multiple substrates and products and that altered AGXT2 activity may contribute to the pathogenesis of cardiovascular, renal, neurological, and hematological diseases. This article reviews the biochemical properties and physiological functions of AGXT2, its unique role at the intersection of key mitochondrial pathways, and its potential as a drug target.
Details
- Title: Subtitle
- AGXT2: a promiscuous aminotransferase
- Creators
- Roman N. Rodionov - University Hospital Carl Gustav CarusNatalia Jarzebska - University Hospital Carl Gustav CarusNorbert Weiss - University Hospital Carl Gustav CarusSteven R. Lentz - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Trends in pharmacological sciences (Regular ed.), Vol.35(11), pp.31-38
- Publisher
- Elsevier
- DOI
- 10.1016/j.tips.2014.09.005
- PMID
- 25294000
- PMCID
- PMC4254113
- ISSN
- 0165-6147
- eISSN
- 1873-3735
- Number of pages
- 8
- Grant note
- P01 NS024621 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) P01NS024621 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01 HL063943 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01HL063943 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 11/01/2014
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359580702771
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