Journal article
AHP DB: a reference database of proteins in the human aqueous humor
Database : the journal of biological databases and curation, Vol.2024, 001
01/29/2024
DOI: 10.1093/database/baae001
PMCID: PMC10878049
PMID: 38284936
Abstract
The aqueous humor (AH) is a low-viscosity biofluid that continuously circulates from the posterior chamber to the anterior chamber of the eye. Recent advances in high-resolution mass-spectrometry workflows have facilitated the study of proteomic content in small-volume biofluids like AH, highlighting the potential clinical implications of the AH proteome. Nevertheless, in-depth investigations into the role of AH proteins in ocular diseases have encountered challenges due to limited accessibility to these workflows, difficulties in large-scale AH sample collection and the absence of a reference AH proteomic database. In response to these obstacles, and to promote further research on the involvement of AH proteins in ocular physiology and pathology, we have developed the web-based Aqueous Humor Proteomics Database (AHP DB). The current version of AHP DB contains proteomic data from 307 human AH samples, which were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The database offers comprehensive information on 1683 proteins identified in the AH samples. Furthermore, relevant clinical data are provided for each analyzed sample. Researchers also have the option to download these datasets individually for offline use, rendering it a valuable resource for the scientific community.Database URL: https://ahp.augusta.edu/
Details
- Title: Subtitle
- AHP DB: a reference database of proteins in the human aqueous humor
- Creators
- Tae Jin Lee - Augusta UniversityArnav Goyal - Augusta UniversityGarrett Jones - Augusta UniversityJoshua Glass - Augusta UniversityVishal Doshi - Augusta UniversityKathryn Bollinger - Augusta UniversityLane Ulrich - Augusta UniversitySaleh Ahmed - Augusta UniversitySai Karthik Kodeboyina - Augusta UniversityAmy Estes - Augusta UniversityMarc Toeteberg-Harms - Augusta UniversityWenbo Zhi - Augusta UniversityShruti Sharma - Augusta UniversityAshok Sharma - Augusta University
- Resource Type
- Journal article
- Publication Details
- Database : the journal of biological databases and curation, Vol.2024, 001
- Publisher
- Oxford Univ Press
- DOI
- 10.1093/database/baae001
- PMID
- 38284936
- PMCID
- PMC10878049
- ISSN
- 1758-0463
- eISSN
- 1758-0463
- Number of pages
- 8
- Grant note
- P30-EY031631 / Center Core Grant for Vision Research R01-EY029728 / National Institutes of Health (NIH) (Bethesda, MD, USA); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 01/29/2024
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984696579202771
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