Journal article
AKI and Genetics: Evolving Concepts in the Genetics of Acute Kidney Injury: Implications for Pediatric AKI
Journal of pediatric genetics (Birmingham, Ala.), Vol.5(1), pp.061-068
03/2016
DOI: 10.1055/s-0035-1557112
PMCID: PMC4918705
PMID: 27617143
Abstract
Abstract
In spite of recent advances in the field of acute kidney injury (AKI) research, morbidity and mortality remain high for AKI sufferers. The study of genetic influences in AKI pathways is an evolving field with potential for improving outcomes through the identification of risk and protective factors at the individual level that may in turn allow for the development of rational therapeutic interventions. Studies of single nucleotide polymorphisms, individual susceptibility to nephrotoxic medications, and epigenetic factors comprise a growing body of research in this area. While promising, this field is still only emerging, with a small number of studies in humans and very little data in pediatric patients.
Details
- Title: Subtitle
- AKI and Genetics: Evolving Concepts in the Genetics of Acute Kidney Injury: Implications for Pediatric AKI
- Creators
- Kathy Lee-Son - Division of Pediatric Nephrology, Dialysis, and Transplantation, University of Iowa Children's HospitalJennifer G Jetton - Division of Pediatric Nephrology, Dialysis, and Transplantation, University of Iowa Children's Hospital, Iowa City, Iowa, United States
- Resource Type
- Journal article
- Publication Details
- Journal of pediatric genetics (Birmingham, Ala.), Vol.5(1), pp.061-068
- Publisher
- Georg Thieme Verlag KG
- DOI
- 10.1055/s-0035-1557112
- PMID
- 27617143
- PMCID
- PMC4918705
- ISSN
- 2146-4596
- eISSN
- 2146-460X
- Language
- English
- Date published
- 03/2016
- Academic Unit
- Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics
- Record Identifier
- 9984093366102771
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