Journal article
ALS Multicenter Cohort Study of Oxidative Stress (ALS COSMOS): Study methodology, recruitment, and baseline demographic and disease characteristics
Amyotrophic lateral sclerosis and frontotemporal degeneration, Vol.15(3-4), pp.192-203
06/01/2014
DOI: 10.3109/21678421.2013.864312
PMCID: PMC4310702
PMID: 24564738
Abstract
In a multicenter study of newly diagnosed ALS patients without a reported family history of ALS, we are prospectively investigating whether markers of oxidative stress (OS) are associated with disease progression. Methods utilize an extensive structured telephone interview ascertaining environmental, lifestyle, dietary and psychological risk factors associated with OS. Detailed assessments were performed at baseline and at 3-6 month intervals during the ensuing 30 months. Our biorepository includes DNA, plasma, urine, and skin. Three hundred and fifty-five patients were recruited. Subjects were enrolled over a 36-month period at 16 sites. To meet the target number of subjects, the recruitment period was prolonged and additional sites were included. Results showed that demographic and disease characteristics were similar between 477 eligible/non-enrolled and enrolled patients, the only difference being type of health insurance among enrolled patients. Sites were divided into three groups by the number of enrolled subjects. Comparing these three groups, the Columbia site had fewer 'definite ALS' diagnoses. This is the first prospective, interdisciplinary, in-depth, multicenter epidemiological investigation of OS related to ALS progression and has been accomplished by an aggressive recruitment process. The baseline demographic and disease features of the study sample are now fully characterized.
Details
- Title: Subtitle
- ALS Multicenter Cohort Study of Oxidative Stress (ALS COSMOS): Study methodology, recruitment, and baseline demographic and disease characteristics
- Creators
- Hiroshi Mitsumoto - Eleanor and Lou Gehrig MDA/ALS Research Center, Department of Neurology, Columbia University Medical CenterPam Factor-Litvak - Department of Epidemiology, Mailman School of Public HealthHoward Andrews - Data Coordinating Center (DCC), Mailman School of Public Health Biostatistics DepartmentRaymond R Goetz - New York State Psychiatric Institute and Department of PsychiatryLeslie Andrews - Department of Environmental Health Sciences, Mailman School of Public Health, Columbia UniversityJudith G Rabkin - New York State Psychiatric Institute and Department of PsychiatryMartin McElhiney - New York State Psychiatric Institute and Department of PsychiatryJeri Nieves - Clinical Research CenterRegina M Santella - Department of Environmental Health Sciences, Mailman School of Public Health, Columbia UniversityJennifer Murphy - Department of Neurology, University of CaliforniaJonathan Hupf - Eleanor and Lou Gehrig MDA/ALS Research Center, Department of Neurology, Columbia University Medical CenterJess Singleton - Eleanor and Lou Gehrig MDA/ALS Research Center, Department of Neurology, Columbia University Medical CenterDavid Merle - Data Coordinating Center (DCC), Mailman School of Public Health Biostatistics DepartmentMary Kilty - Department of Epidemiology, Mailman School of Public HealthDaragh HeitzmanRichard S Bedlack - Department of Neurology, Duke UniversityRobert G Miller - Forbes Norris ALS Center, California Pacific Medical CenterJonathan S Katz - Forbes Norris ALS Center, California Pacific Medical CenterDallas Forshew - Forbes Norris ALS Center, California Pacific Medical CenterRichard J Barohn - Department of Neurology, University of KansasEric J Sorenson - Mayo ClinicBjorn Oskarsson - Department of Neurology, University of CaliforniaJ. Americo M Fernandes Filho - Department of Neurological Sciences, University of Nebraska Medical CenterEdward J Kasarskis - Department of Neurology, University of KentuckyCatherine Lomen-Hoerth - Department of Neurology, University of CaliforniaTahseen Mozaffar - Department of Neurology, University of CaliforniaYvonne D Rollins - Department of Neurology, University of Colorado AuroraSharon P Nations - Department of Neurology and Neurotherapeutics, University of Texas SouthwesternAndrea J Swenson - Department of Neurology, University of IowaJeremy M Shefner - Department of Neurology, SUNY - Upstate Medical UniversityJinsy A Andrews - Department of Neurology, Hospital for Special CareBoguslawa A Koczon-Jaremko - Department of Neurology, Hospital for Special Care
- Resource Type
- Journal article
- Publication Details
- Amyotrophic lateral sclerosis and frontotemporal degeneration, Vol.15(3-4), pp.192-203
- DOI
- 10.3109/21678421.2013.864312
- PMID
- 24564738
- PMCID
- PMC4310702
- NLM abbreviation
- Amyotroph Lateral Scler Frontotemporal Degener
- ISSN
- 2167-8421
- eISSN
- 2167-9223
- Publisher
- Taylor & Francis
- Language
- English
- Date published
- 06/01/2014
- Academic Unit
- Neurology
- Record Identifier
- 9984014018502771
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