AP-2α and AP-2β cooperatively orchestrate homeobox gene expression during branchial arch patterning

Eric Van Otterloo; Hong Li; Kenneth L Jones; Trevor Williams

doi:10.1242/dev.157438

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AP-2α and AP-2β cooperatively orchestrate homeobox gene expression during branchial arch patterning

Journal article

Open access

Peer reviewed

AP-2α and AP-2β cooperatively orchestrate homeobox gene expression during branchial arch patterning

Eric Van Otterloo, Hong Li, Kenneth L Jones and Trevor Williams

Development (Cambridge), Vol.145(2), pp.dev157438-dev157438

01/25/2018

DOI: 10.1242/dev.157438

PMCID: PMC5825845

PMID: 29229773

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https://doi.org/10.1242/dev.157438View

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Abstract

The evolution of a hinged moveable jaw with variable morphology is considered a major factor behind the successful expansion of the vertebrates. DLX homeobox transcription factors are crucial for establishing the positional code that patterns the mandible, maxilla and intervening hinge domain, but how the genes encoding these proteins are regulated remains unclear. Herein, we demonstrate that the concerted action of the AP-2α and AP-2β transcription factors within the mouse neural crest is essential for jaw patterning. In the absence of these two proteins, the hinge domain is lost and there are alterations in the size and patterning of the jaws correlating with dysregulation of homeobox gene expression, with reduced levels of Emx, Msx and Dlx paralogs accompanied by an expansion of expression. Moreover, detailed analysis of morphological features and gene expression changes indicate significant overlap with various compound Dlx gene mutants. Together, these findings reveal that the AP-2 genes have a major function in mammalian neural crest development, influencing patterning of the craniofacial skeleton via the DLX code, an effect that has implications for vertebrate facial evolution, as well as for human craniofacial disorders.

Animals

Body Patterning - physiology

Branchial Region - cytology

Branchial Region - embryology

Gene Expression Regulation, Developmental - physiology

Homeodomain Proteins - biosynthesis

Homeodomain Proteins - genetics

Mice

Mice, Transgenic

Neural Crest - cytology

Neural Crest - metabolism

Transcription Factor AP-2 - genetics

Transcription Factor AP-2 - metabolism

Details

Title: Subtitle: AP-2α and AP-2β cooperatively orchestrate homeobox gene expression during branchial arch patterning
Creators: Eric Van Otterloo - University of Colorado Anschutz Medical Campus
Hong Li - University of Colorado Anschutz Medical Campus
Kenneth L Jones - University of Colorado Denver
Trevor Williams - Children's Hospital Colorado
Resource Type: Journal article
Publication Details: Development (Cambridge), Vol.145(2), pp.dev157438-dev157438
DOI: 10.1242/dev.157438
PMID: 29229773
PMCID: PMC5825845
NLM abbreviation: Development
ISSN: 0950-1991
eISSN: 1477-9129
Grant note: K99 DE026823 / NIDCR NIH HHS
Language: English
Date published: 01/25/2018
Academic Unit: Anatomy and Cell Biology; Craniofacial Anomalies Research Center; Dental Research; Periodontics
Record Identifier: 9984284333802771

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