Journal article
APE1/Ref-1: Versatility in Progress
Antioxidants & redox signaling, Vol.11(3), pp.571-574
03/2009
DOI: 10.1089/ars.2008.2223
PMID: 18715142
Abstract
Apurinic/apyrimidinic endonuclease1/redox factor-1 (APE1/Ref-1) is a multifunctional protein involved in base excision DNA repair and in transcriptional regulation of gene expression. Over the past decade and a half, knowledge of the biological functions, interactions, mechanisms of action, and regulation of the protein APE1/Ref-1 has grown exponentially. The multifunctional nature of APE1/Ref-1 is uncovering and has been extensively studied in the cellular response against oxidative stress. Recent evidence shows a biological role of APE1/Ref-1 can be modulated by the different post-translational modification. Because of APE1/Ref-1 importance to genomic stability and cell survival, APE1/Ref-1 is focused as the leading therapeutic target molecule for the oxidative stress condition or pathologic conditions such as cancer. This forum, dedicated to APE1/Ref-1, provides ample testimony that even though we have learned a great deal about APE1/Ref-1 over the past 15-plus years, our knowledge still constitutes the tip of the iceberg when it comes to understanding this versatile protein.
Details
- Title: Subtitle
- APE1/Ref-1: Versatility in Progress
- Creators
- Byeong Hwa Jeon - Infection Signaling Network Research Center, Department of Physiology, College of Medicine, Chungnam National University, Daejeon, KoreaKaikobad Irani - Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
- Resource Type
- Journal article
- Publication Details
- Antioxidants & redox signaling, Vol.11(3), pp.571-574
- DOI
- 10.1089/ars.2008.2223
- PMID
- 18715142
- ISSN
- 1523-0864
- eISSN
- 1557-7716
- Language
- English
- Date published
- 03/2009
- Academic Unit
- Cardiovascular Medicine; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984047737002771
Metrics
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