Journal article
APE1/Ref-1 as a Serological Biomarker for the Detection of Bladder Cancer
Cancer research and treatment, Vol.47(4), pp.823-833
10/2015
DOI: 10.4143/crt.2014.074
PMCID: PMC4614188
PMID: 25672588
Abstract
Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that shows elevated expression in a number of cancers. We attempted to determine whether serum APE1/Ref-1 is elevated in patients with bladder cancer.
Serum APE1/Ref-1 levels were determined using enzyme-linked immunosorbent assay in serum from patients with bladder cancer who had not received chemotherapy or radiotherapy (n=51) and non-tumor controls (n=55). The area under the receiver operating characteristic area under the curve was applied to determine the correlation between clinical factors and the serum levels of APE1/Ref-1.
Serum levels of APE1/Ref-1 in bladder cancer patients were significantly elevated compared to those of the control group (3.548 ± 0.333 ng/100 μL [n=51] for bladder cancer vs. 1.547 ± 0.319 ng/100 μL [n=55] for the control group), with a sensitivity and specificity of 93% and 59%, respectively. Serum APE1/Ref-1 levels are associated with tumor stage, grade, muscle invasion, and recurrence.
Serum APE1/Ref-1 might be useful as a potential serologic biomarker for bladder cancer.
Details
- Title: Subtitle
- APE1/Ref-1 as a Serological Biomarker for the Detection of Bladder Cancer
- Creators
- Ju Hyun Shin - Department of Urology, Chungnam National University Hospital, Daejeon, KoreaSunga Choi - Infection Signaling Network Research Center, Research Institute of Medical Sciences, Department of Physiology, Chungnam National University School of Medicine, Daejeon, KoreaYu Ran Lee - Infection Signaling Network Research Center, Research Institute of Medical Sciences, Department of Physiology, Chungnam National University School of Medicine, Daejeon, KoreaMyoung Soo Park - Infection Signaling Network Research Center, Research Institute of Medical Sciences, Department of Physiology, Chungnam National University School of Medicine, Daejeon, KoreaYong Gil Na - Department of Urology, Chungnam National University Hospital, Daejeon, KoreaKaikobad Irani - Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USASang Do Lee - Infection Signaling Network Research Center, Research Institute of Medical Sciences, Department of Physiology, Chungnam National University School of Medicine, Daejeon, KoreaJin Bong Park - Infection Signaling Network Research Center, Research Institute of Medical Sciences, Department of Physiology, Chungnam National University School of Medicine, Daejeon, KoreaJin Man Kim - Department of Pathology, Chungnam National University School of Medicine, Daejeon, KoreaJae Sung Lim - Department of Urology, Chungnam National University Hospital, Daejeon, KoreaByeong Hwa Jeon - Infection Signaling Network Research Center, Research Institute of Medical Sciences, Department of Physiology, Chungnam National University School of Medicine, Daejeon, Korea
- Resource Type
- Journal article
- Publication Details
- Cancer research and treatment, Vol.47(4), pp.823-833
- Publisher
- Korea (South)
- DOI
- 10.4143/crt.2014.074
- PMID
- 25672588
- PMCID
- PMC4614188
- ISSN
- 1598-2998
- eISSN
- 2005-9256
- Grant note
- DOI: 10.13039/501100003725, name: National Research Foundation of Korea (NRF), award: 2011-0006231, M2013DD001
- Language
- English
- Date published
- 10/2015
- Academic Unit
- Cardiovascular Medicine; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984047679202771
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