APO-9'-Fucoxanthinone Extracted from Undariopsis peteseniana Protects Oxidative Stress-Mediated Apoptosis in Cigarette Smoke-Exposed Human Airway Epithelial Cells

Jun-Ho Jang; Ji-Hyeok Lee; Hitendra S Chand; Jong-Soo Lee; Yong Lin; Nathaniel Weathington; Rama Mallampalli; You-Jin Jeon; Toru Nyunoya

doi:10.3390/md14070140

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APO-9'-Fucoxanthinone Extracted from Undariopsis peteseniana Protects Oxidative Stress-Mediated Apoptosis in Cigarette Smoke-Exposed Human Airway Epithelial Cells

Journal article

Peer reviewed

APO-9'-Fucoxanthinone Extracted from Undariopsis peteseniana Protects Oxidative Stress-Mediated Apoptosis in Cigarette Smoke-Exposed Human Airway Epithelial Cells

Jun-Ho Jang, Ji-Hyeok Lee, Hitendra S Chand, Jong-Soo Lee, Yong Lin, Nathaniel Weathington, Rama Mallampalli, You-Jin Jeon and Toru Nyunoya

Marine drugs, Vol.14(7), p.140

07/21/2016

DOI: 10.3390/md14070140

PMID: 27455285

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Abstract

Long-term cigarette smoking increases the risk for chronic obstructive pulmonary disease (COPD), characterized by irreversible expiratory airflow limitation. The pathogenesis of COPD involves oxidative stress and chronic inflammation. Various natural marine compounds possess both anti-oxidant and anti-inflammatory properties, but few have been tested for their efficacy in COPD models. In this study, we conducted an in vitro screening test to identify natural compounds isolated from various brown algae species that might provide protection against cigarette smoke extract (CSE)-induced cytotoxicity. Among nine selected natural compounds, apo-9'-fucoxanthinone (Apo9F) exhibited the highest protection against CSE-induced cytotoxicity in immortalized human bronchial epithelial cells (HBEC2). Furthermore, the protective effects of Apo9F were observed to be associated with a significant reduction in apoptotic cell death, DNA damage, and the levels of mitochondrial reactive oxygen species (ROS) released from CSE-exposed HBEC2 cells. These results suggest that Apo9F protects against CSE-induced DNA damage and apoptosis by regulating mitochondrial ROS production.

Apoptosis - drug effects

Cell Line

DNA Damage - drug effects

Epithelial Cells - drug effects

Epithelial Cells - metabolism

Humans

Mitochondria - drug effects

Mitochondria - metabolism

Nicotiana - adverse effects

Oxidative Stress - drug effects

Protective Agents - chemistry

Protective Agents - pharmacology

Pulmonary Disease, Chronic Obstructive - etiology

Pulmonary Disease, Chronic Obstructive - metabolism

Reactive Oxygen Species - metabolism

Rhodophyta - chemistry

Smoke - adverse effects

Smoking - adverse effects

Terpenes - chemistry

Terpenes - pharmacology

Details

Title: Subtitle: APO-9'-Fucoxanthinone Extracted from Undariopsis peteseniana Protects Oxidative Stress-Mediated Apoptosis in Cigarette Smoke-Exposed Human Airway Epithelial Cells
Creators: Jun-Ho Jang - University of Pittsburgh
Ji-Hyeok Lee - Jeju National University
Hitendra S Chand - Lovelace Respiratory Research Institute
Jong-Soo Lee - Gyeongsang National University
Yong Lin - Lovelace Respiratory Research Institute
Nathaniel Weathington - University of Pittsburgh
Rama Mallampalli - University of Pittsburgh
You-Jin Jeon - Jeju National University
Toru Nyunoya - University of Pittsburgh
Resource Type: Journal article
Publication Details: Marine drugs, Vol.14(7), p.140
DOI: 10.3390/md14070140
PMID: 27455285
ISSN: 1660-3397
eISSN: 1660-3397
Grant note: R01 HL098174 / NHLBI NIH HHS I01 CX001048 / CSRD VA P01 HL114453 / NHLBI NIH HHS R01 HL096376 / NHLBI NIH HHS R21 AI117560 / NIAID NIH HHS
Language: English
Date published: 07/21/2016
Academic Unit: Internal Medicine
Record Identifier: 9985214167602771

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