Journal article
APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema
The European respiratory journal, Vol.43(4), pp.1003-1017
2014
DOI: 10.1183/09031936.00147612
PMID: 23900982
Abstract
Chronic obstructive pulmonary disease (COPD) is linked to cardiovascular disease; however, there are few studies on the associations of cardiovascular genes with COPD.
We assessed the association of lung function with 2100 genes selected for cardiovascular diseases among 20 077 European-Americans and 6900 African-Americans. We performed replication of significant loci in the other racial group and an independent consortium of Europeans, tested the associations of significant loci with per cent emphysema and examined gene expression in an independent sample. We then tested the association of a related lipid biomarker with forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio and per cent emphysema.
We identified one new polymorphism for FEV1/FVC (rs805301) in European-Americans (p=1.3×10−6) and a second (rs707974) in the combined European-American and African-American analysis (p=1.38×10−7). Both single-nucleotide polymorphisms (SNPs) flank the gene for apolipoprotein M (APOM), a component of high-density lipoprotein (HDL) cholesterol. Both were replicated in an independent cohort. SNPs in a second gene related to apolipoprotein M and HDL, PCSK9, were associated with FEV1/FVC ratio among African-Americans. rs707974 was associated with per cent emphysema among European-Americans and African-Americans and APOM expression was related to FEV1/FVC ratio and per cent emphysema. Higher HDL levels were associated with lower FEV1/FVC ratio and greater per cent emphysema.
These findings suggest a novel role for the apolipoprotein M/HDL pathway in the pathogenesis of COPD and emphysema.
Details
- Title: Subtitle
- APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema
- Creators
- Charles A POWELL - Dept of Medicine, Mount Sinai Hospital, New York, NY, United StatesJemma B WILK - Dept of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United StatesSusan REDLINE - Dept of Medicine, Brigham and Women's Hospital, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United StatesJerome I ROTTER - Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesLewis J SMITH - Dept of Medicine, Northwestern University, Chicago, IL, United StatesMaría Soler ARTIGAS - Dept of Health Sciences, Genetic Epidemiology Group, University of Leicester, Leicester, United KingdomMartin D TOBIN - Dept of Health Sciences, Genetic Epidemiology Group, University of Leicester, Leicester, United KingdomMichael Y TSAI - Dept of Laboratory Medical Pathology, University of Minnesota, Minneapolis, MN, United StatesKarol WATSON - Dept of Medicine University of California Los Angeles, Las Angeles, CA, United StatesWendy WHITE - Jackson Heart Study, Tougaloo College, Tougaloo, MS, United StatesKristin M BURKART - Dept of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, United StatesTaylor R YOUNG - The Broad Institute of MIT and Harvard, Cambridge, MA, United StatesAni MANICHAIKUL - Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, United StatesStephen S RICH - Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, United StatesJoel D KAUFMAN - Depts of Environmental and Occupational Health Sciences, Medicine, and Epidemiology, University of Washington, Seattle, WA, United StatesFiras S AHMED - Depts of Medicine and Radiology, College of Physicians and Surgeons, Columbia University, New York, NY, United StatesJun Kurai - Dept of Medicine, Mount Sinai Hospital, New York, NY, United StatesR. Graham BARR - Dept of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, United StatesLaura LOEHR - Dept of Epidemiology, University of North Carolina, Chapel Hill, NC, United StatesGregory L BURKE - Dept of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, United StatesStephanie J LONDON - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health and Human Services, Research Triangle Park, NC, United StatesPaul ENRIGHT - Dept of Medicine, University of Arizona, Tucson, AZ, United StatesYang Meng - The Broad Institute of MIT and Harvard, Cambridge, MA, United StatesNadia N HANSEL - Dept of Medicine, Johns Hopkins University, Baltimore, MD, United StatesGeorge T O'CONNOR - Pulmonary Center, Dept of Medicine, Boston University School of Medicine, Boston, MA, United StatesDemondes HAYNES - Dept of Medicine, University of Mississippi, Jackson, MS, United StatesElizabeth OELSNER - Dept of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, United StatesSusan R HECKBERT - Dept of Epidemiology, School of Public Health, University of Washington, Seattle, WA, United StatesMarcy PETRINI - Dept of Medicine, University of Mississippi, Jackson, MS, United StatesEric A HOFFMAN - Dept of Radiology, University of Iowa, Iowa City, IA, United StatesTess D POTTINGER - Dept of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, United States
- Resource Type
- Journal article
- Publication Details
- The European respiratory journal, Vol.43(4), pp.1003-1017
- Publisher
- Maney; Leeds
- DOI
- 10.1183/09031936.00147612
- PMID
- 23900982
- ISSN
- 0903-1936
- eISSN
- 1399-3003
- Language
- English
- Date published
- 2014
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051733202771
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