APOSTEL-R Recommendations for Reporting Retinal Optical Coherence Tomography Studies in Rodents

Frederike Cosima Oertel; Delia Cabrera Debuc; Peter A Calabresi; Mei Chen; Christian Cordano; Michael Dietrich; Nicolas Feltgen; Oliver Gramlich; Ari J Green; Janos Groh; Su-Chun Huang; Benjamin Knier; Thomas Korn; Letizia Leocani; Anat Loewenstein; Christian van Oterendorp; Tunde Peto; Sven Schippling; Leopold Schmetterer; Steffen Schmitz-Valckenberg; Mathias W Seeliger; Kenneth S Shindler; Joel S Schuman; Mustafa Sindi; Adnan Tufail; Jui-Kai Wang; Sebastian Wolf; Yuyi You; Martin Zinkernagel; Wolf Lagrèze; Philipp Albrecht; IMSVISUAL consortium

doi:10.1212/NXI.0000000000200489

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APOSTEL-R Recommendations for Reporting Retinal Optical Coherence Tomography Studies in Rodents

Journal article

Open access

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APOSTEL-R Recommendations for Reporting Retinal Optical Coherence Tomography Studies in Rodents

Frederike Cosima Oertel, Delia Cabrera Debuc, Peter A Calabresi, Mei Chen, Christian Cordano, Michael Dietrich, Nicolas Feltgen, Oliver Gramlich, Ari J Green, Janos Groh, …

Neurology : neuroimmunology & neuroinflammation, Vol.12(6), e200489

11/01/2025

DOI: 10.1212/NXI.0000000000200489

PMCID: PMC12509961

PMID: 41061181

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Abstract

Retinal optical coherence tomography (OCT) in rodent models has been used to longitudinally image retinal changes, to define end points for more costly or time-consuming experiments, and to better understand the pathophysiology underlying OCT findings in human diseases. No standardization of rodent OCT reporting currently exists. Here, we aim to establish consensus recommendation for reporting results from retinal OCT studies in rodents. Initial recommendations were developed based on the APOSTEL criteria for quantitative OCT reporting in humans by a core team. Using a modified Delphi process, an expert panel of rodent OCT researchers (N = 31) and the wider scientific community discussed, refined, and voted on these initial recommendations. The list of recommendations was then revised and approved by the expert panel. The final 7-point checklist includes reporting recommendations regarding the study protocol, OCT device, acquisition settings and modifications, scanning protocol, funduscopic imaging, postacquisition data selection and image data analyses, and qualitative and quantitative results. With a median agreement score of 3 or 4 out of 4, the scientific community agreed with these recommendations. After revisions, the expert panel accepted the final recommendations. The Advised Protocol for OCT Study Terminology and Elements for reporting OCT studies in rodents (APOSTEL-R) originates from an expert consensus. They will provide guidance throughout the experimental process and will contribute to the standardization and quality improvement of preclinical OCT studies.

Animals

Consensus

Rats

Retina - diagnostic imaging

Rodentia

Tomography, Optical Coherence - methods

Tomography, Optical Coherence - standards

Details

Title: Subtitle: APOSTEL-R Recommendations for Reporting Retinal Optical Coherence Tomography Studies in Rodents
Creators: Frederike Cosima Oertel - Humboldt-Universität zu Berlin
Delia Cabrera Debuc - University of Miami
Peter A Calabresi - Johns Hopkins University
Mei Chen - Queen's University Belfast
Christian Cordano - University of California, San Francisco
Michael Dietrich - Düsseldorf University Hospital
Nicolas Feltgen - University Hospital of Basel
Oliver Gramlich - Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, IA
Ari J Green - University of California, San Francisco
Janos Groh - German Center for Neurodegenerative Diseases
Su-Chun Huang - Department of Neurology, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genova, Italy
Benjamin Knier - München Klinik Schwabing
Thomas Korn - Munich Cluster for Systems Neurology
Letizia Leocani - Vita-Salute San Raffaele University
Anat Loewenstein - Tel Aviv University
Christian van Oterendorp - Universitätsmedizin Göttingen
Tunde Peto - Queen's University Belfast
Sven Schippling - University Hospital of Zurich
Leopold Schmetterer - Statistics Austria
Steffen Schmitz-Valckenberg - University of Bonn
Mathias W Seeliger - STZ eyetrial
Kenneth S Shindler - Penn Presbyterian Medical Center
Joel S Schuman - Thomas Jefferson University
Mustafa Sindi - Düsseldorf University Hospital
Adnan Tufail - MRC Prion Unit
Jui-Kai Wang - The University of Texas Southwestern Medical Center
Sebastian Wolf - University Hospital of Bern
Yuyi You - Ingham Institute
Martin Zinkernagel - University Hospital of Bern
Wolf Lagrèze - University Medical Center Freiburg
Philipp Albrecht - Düsseldorf University Hospital
IMSVISUAL consortium
Resource Type: Journal article
Publication Details: Neurology : neuroimmunology & neuroinflammation, Vol.12(6), e200489
DOI: 10.1212/NXI.0000000000200489
PMID: 41061181
PMCID: PMC12509961
NLM abbreviation: Neurol Neuroimmunol Neuroinflamm
ISSN: 2332-7812
eISSN: 2332-7812
Language: English
Date published: 11/01/2025
Academic Unit: Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9985147199302771

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