ARISE II Consensus on the Management of Intracranial Atherosclerotic Disease

Stavropoula I Tjoumakaris; Joanna M Roy; Sepideh Amin-Hanjani; Fady T Charbel; Guilherme Dabus; Marc Fisher; Matthew Gounis; Brian L Hoh; David S Liebeskind; Italo Linfante; Edgar A Samaniego; Gabor Toth; Osama O Zaidat; Pervinder Bhogal; Adam Arthur; Ajay K Wakhloo; ARISE II Academic Industry Roundtable

doi:10.1161/STROKEAHA.124.050336

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ARISE II Consensus on the Management of Intracranial Atherosclerotic Disease

Journal article

Peer reviewed

ARISE II Consensus on the Management of Intracranial Atherosclerotic Disease

Stavropoula I Tjoumakaris, Joanna M Roy, Sepideh Amin-Hanjani, Fady T Charbel, Guilherme Dabus, Marc Fisher, Matthew Gounis, Brian L Hoh, David S Liebeskind, Italo Linfante, …

Stroke (1970), Vol.56(6), pp.1636-1641

06/2025

DOI: 10.1161/STROKEAHA.124.050336

PMID: 40408521

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Abstract

Intracranial atherosclerotic disease (ICAD) is one of the leading causes of ischemic stroke worldwide. Despite advances in its diagnosis and management, there is no clear consensus on best practices to manage ICAD. This report summarizes the ARISE II (Roundtable Discussion With Industry and Stroke Experts) consensus in treating ICAD. The consensus underscored the importance of lifestyle modification and medical management in patients with ICAD. Patients who fail medical management are candidates for endovascular treatment. Open surgery is not recommended in patients who lack demonstrated hemodynamic insufficiency. The consensus also identified gaps in knowledge about the optimal duration of antithrombotics, the effect of the CYP2C19 genotype on medical management, the need for newer devices, and the standardization of antithrombotic protocols before stenting in an acute setting. Optical coherence tomography requires additional clinical data before defining its role in the diagnosis of ICAD.

Consensus

Disease Management

Endovascular Procedures

Fibrinolytic Agents - therapeutic use

Humans

Intracranial Arteriosclerosis - diagnosis

Intracranial Arteriosclerosis - therapy

Ischemic Stroke - therapy

Stents

Details

Title: Subtitle: ARISE II Consensus on the Management of Intracranial Atherosclerotic Disease
Creators: Stavropoula I Tjoumakaris - Thomas Jefferson University Hospital
Joanna M Roy - Thomas Jefferson University Hospital
Sepideh Amin-Hanjani - University Hospitals of Cleveland
Fady T Charbel - University of Illinois Urbana-Champaign
Guilherme Dabus - Baptist Health South Florida
Marc Fisher - Beth Israel Deaconess Medical Center
Matthew Gounis - University of Massachusetts Chan Medical School
Brian L Hoh - University of Florida
David S Liebeskind - University of California, Los Angeles
Italo Linfante - Baptist Hospital of Miami
Edgar A Samaniego - University of Iowa Hospitals and Clinics
Gabor Toth - Cleveland Clinic
Osama O Zaidat - Bon Secours Mercy Health
Pervinder Bhogal - Barts Health NHS Trust
Adam Arthur - University of Tennessee Health Science Center
Ajay K Wakhloo - Tufts University
ARISE II Academic Industry Roundtable
Resource Type: Journal article
Publication Details: Stroke (1970), Vol.56(6), pp.1636-1641
Publisher: LIPPINCOTT WILLIAMS & WILKINS; PHILADELPHIA
DOI: 10.1161/STROKEAHA.124.050336
PMID: 40408521
ISSN: 0039-2499
eISSN: 1524-4628
Language: English
Date published: 06/2025
Academic Unit: Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984824296402771

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