Journal article
ASICs Mediate Pain and Inflammation in Musculoskeletal Diseases
Physiology (Bethesda, Md.), Vol.30(6), pp.449-459
11/2015
DOI: 10.1152/physiol.00030.2015
PMCID: PMC4747907
PMID: 26525344
Abstract
Chronic musculoskeletal pain is debilitating and affects ∼ 20% of adults. Tissue acidosis is present in painful musculoskeletal diseases like rheumatoid arthritis. ASICs are located on skeletal muscle and joint nociceptors as well as on nonneuronal cells in the muscles and joints, where they mediate nociception. This review discusses the properties of different types of ASICs, factors affecting their pH sensitivity, and their role in musculoskeletal hyperalgesia and inflammation.
Details
- Title: Subtitle
- ASICs Mediate Pain and Inflammation in Musculoskeletal Diseases
- Creators
- Ramy E Abdelhamid - Department of Physical Therapy and Rehabilitation Science, Neuroscience Graduate Program, Pain Research Program, University of Iowa, Iowa City, IowaKathleen A Sluka - Department of Physical Therapy and Rehabilitation Science, Neuroscience Graduate Program, Pain Research Program, University of Iowa, Iowa City, Iowa kathleen-sluka@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Physiology (Bethesda, Md.), Vol.30(6), pp.449-459
- Publisher
- United States
- DOI
- 10.1152/physiol.00030.2015
- PMID
- 26525344
- PMCID
- PMC4747907
- ISSN
- 1548-9213
- eISSN
- 1548-9221
- Grant note
- R01 AR061371 / NIAMS NIH HHS
- Language
- English
- Date published
- 11/2015
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984040390802771
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