Journal article
ASICs are required for immediate exercise-induced muscle pain and are downregulated in sensory neurons by exercise training
Journal of applied physiology (1985), Vol.129(1), pp.17-26
07/01/2020
DOI: 10.1152/japplphysiol.00033.2020
PMID: 32463731
Abstract
Exercise performance can be limited by the sensations of muscle fatigue and pain transmitted by muscle afferents. It has been proposed that exercise training abrogates these negative feedback signals. We found that acid-sensing ion channels (ASICs) are required for immediate exercise-induced muscle pain (IEIP). Moreover, exercise training prevented IEIP and was correlated with downregulation of ASICs in sensory neurons.
Exercise training is an effective therapy for many pain-related conditions, and trained athletes have lower pain perception compared with unconditioned people. Some painful conditions, including strenuous exercise, are associated with elevated levels of protons, metabolites, and inflammatory factors, which may activate receptors and/or ion channels, including acid-sensing ion channels (ASICs), on nociceptive sensory neurons. We hypothesized that ASICs are required for immediate exercise-induced muscle pain (IEIP) and that exercise training diminishes IEIP by modulating ASICs within muscle afferents. We found high-intensity interval training (HIIT) reduced IEIP in C57BL/6 mice and diminished ASIC mRNA levels in lumber dorsal root ganglia, and this downregulation of ASICs correlated with improved exercise capacity. Additionally, we found that ASIC3 −/− mice did not develop IEIP; however, the exercise capacity of ASIC3 −/− was similar to wild-type mice. These results suggest that ASICs are required for IEIP and that diminishment of IEIP after exercise training correlates with downregulation of ASICs in sensory neurons. NEW & NOTEWORTHY Exercise performance can be limited by the sensations of muscle fatigue and pain transmitted by muscle afferents. It has been proposed that exercise training abrogates these negative feedback signals. We found that acid-sensing ion channels (ASICs) are required for immediate exercise-induced muscle pain (IEIP). Moreover, exercise training prevented IEIP and was correlated with downregulation of ASICs in sensory neurons.
Details
- Title: Subtitle
- ASICs are required for immediate exercise-induced muscle pain and are downregulated in sensory neurons by exercise training
- Creators
- Tahsin Khataei - Department of Exercise Physiology, Tarbiat Modares University, Tehran, Iran, Department of Internal Medicine, University of Iowa, Roy J. and Lucile A. Carver College of Medicine, Iowa City, Iowa, Iowa City Veterans Affairs Healthcare System, Iowa City, IowaAnne Marie S Harding - Department of Internal Medicine, University of Iowa, Roy J. and Lucile A. Carver College of Medicine, Iowa City, Iowa, Iowa City Veterans Affairs Healthcare System, Iowa City, IowaMahyar Janahmadi - Department of Physiology and Neuroscience Research Center, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, IranMaram El-Geneidy - Department of Internal Medicine, University of Iowa, Roy J. and Lucile A. Carver College of Medicine, Iowa City, Iowa, Iowa City Veterans Affairs Healthcare System, Iowa City, IowaHamid Agha-Alinejad - Department of Exercise Physiology, Tarbiat Modares University, Tehran, IranHamid Rajabi - Department of Exercise Physiology, Kharazmi University, Tehran, IranPeter M Snyder - Department of Internal Medicine, University of Iowa, Roy J. and Lucile A. Carver College of Medicine, Iowa City, Iowa, Iowa City Veterans Affairs Healthcare System, Iowa City, IowaKathleen A Sluka - Department of Physical Therapy and Rehabilitation Science, The University of Iowa, Iowa City, Iowa, Neuroscience Institute, The University of Iowa, Iowa City, IowaChristopher J Benson - Department of Internal Medicine, University of Iowa, Roy J. and Lucile A. Carver College of Medicine, Iowa City, Iowa, Iowa City Veterans Affairs Healthcare System, Iowa City, Iowa, Department of Pharmacology, University of Iowa, Roy J. and Lucile A. Carver College of Medicine, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.129(1), pp.17-26
- DOI
- 10.1152/japplphysiol.00033.2020
- PMID
- 32463731
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Grant note
- DOI: 10.13039/100000738, name: U.S. Department of Veterans Affairs, award: 5I01BX000776
- Language
- English
- Date published
- 07/01/2020
- Academic Unit
- Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Cardiovascular Medicine; Nursing; Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Medicine Administration; Internal Medicine
- Record Identifier
- 9984070592302771
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