Journal article
ATP-Sensitive K+ Channels Mediate Dilatation of Cerebral Arterioles During Hypoxia
Circulation research, Vol.74(5), pp.1005-1008
05/1994
DOI: 10.1161/01.RES.74.5.1005
PMID: 8156623
Abstract
We tested the hypothesis that dilatation of cerebral arterioles during hypoxia is mediated by activation of ATP-sensitive K channels. The diameter of pial arterioles was measured through a closed cranial window in anesthetized rabbits. Topical application of aprikalim (10 mol/L), a direct activator of ATP-sensitive K channels, dilated pial arterioles by 18±3% (mean±SEM). Glibenclamide (10 mol/L), an inhibitor of ATP-sensitive K channels, virtually abolished aprikalim-induced vasodilatation. When arterial Po2 was reduced from 129±3 to 25±1 mm Hg, the diameter of cerebral arterioles increased by 66±9% (P<.05). Glibenclamide inhib ited dilatation of pial arterioles during hypoxia by 46±5% (P<.05). In contrast, vasodilatation in response to sodium nitroprusside was not altered by glibenclamide. Topical application of adenosine (10 mol/L) increased arteriolar diameter by 21±4%. Glibenclamide did not affect adenosine-induced vasodilatation. These findings suggest that dilatation of cerebral arterioles in response to hypoxia is mediated, in part, by activation of ATP-sensitive K channels.
Details
- Title: Subtitle
- ATP-Sensitive K+ Channels Mediate Dilatation of Cerebral Arterioles During Hypoxia
- Creators
- Hisao Taguchi - Departments of Internal Medicine and Pharmacology, Center on Aging and Cardiovascular Center, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa CityDonald HeistadTakanari KitazonoFrank Faraci
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.74(5), pp.1005-1008
- Publisher
- American Heart Association, Inc
- DOI
- 10.1161/01.RES.74.5.1005
- PMID
- 8156623
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Language
- English
- Date published
- 05/1994
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040322702771
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