Journal article
ATP-Sensitive Potassium Channels in the Basilar Artery During Chronic Hypertension
Hypertension (Dallas, Tex. 1979), Vol.22(5), pp.677-681
11/1993
DOI: 10.1161/01.HYP.22.5.677
PMID: 8225527
Abstract
We examined the hypothesis that dilatation of the basilar artery in response to activation of ATP-sensitive potassium channels is impaired in stroke-prone spontaneously hypertensive rats (SHRSP). Changes in basilar artery diameter in response to aprikalim, a direct activator of ATP-sensitive potassium channels, were measured in anesthetized SHRSP and normotensive Wistar-Kyoto (WKY) rats through a cranial window. Topical application of aprikalim increased basilar artery diameter in WKY rats. Glibenclamide, a selective inhibitor of ATP-sensitive potassium channels, abolished aprikalim-induced vasodilatation. Thus, ATP-sensitive potassium channels are functional in the basilar artery of WKY rats in vivo. Aprikalim (10 mol/L) dilated the basilar artery by 31±5% (mean ± SEM) in WKY rats but only 5±1% in SHRSP. The concentration-response curve to aprikalim in SHRSP was significantly shifted to the right, but the response to the highest concentration of aprikalim (10 mol/L) was similar in SHRSP and WKY rats. Vasodilatation in response to norepinephrine was also impaired in SHRSP. Dilator responses of the basilar artery to forskolin, a direct activator of adenylate cyclase, and nitroprusside, a direct activator of guanylate cyclase, were normal in SHRSP. The findings suggest that dilatation of the basilar artery in response to direct activation of ATP-sensitive potassium channels is impaired in SHRSP compared with WKY rats in vivo.
Details
- Title: Subtitle
- ATP-Sensitive Potassium Channels in the Basilar Artery During Chronic Hypertension
- Creators
- Takanari Kitazono - Departments of Internal Medicine and Pharmacology, Center on Aging and the Cardiovascular Center, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa CityDonald HeistadFrank Faraci
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.22(5), pp.677-681
- Publisher
- American Heart Association, Inc
- DOI
- 10.1161/01.HYP.22.5.677
- PMID
- 8225527
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Language
- English
- Date published
- 11/1993
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040486002771
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