Journal article
AUTOPHAGY IN THE EYE: FROM PHYSIOLOGY TO PATHOPHYSOLOGY
Autophagy reports, Vol.2(1), 2178996
2023
DOI: 10.1080/27694127.2023.2178996
PMCID: PMC10078619
PMID: 37034386
Abstract
Autophagy is a catabolic self-degradative pathway that promotes the degradation and recycling of intracellular material through the lysosomal compartment. Although first believed to function in conditions of nutritional stress, autophagy is emerging as a critical cellular pathway, involved in a variety of physiological and pathophysiological processes. Autophagy dysregulation is associated with an increasing number of diseases, including ocular diseases. On one hand, mutations in autophagy-related genes have been linked to cataracts, glaucoma, and corneal dystrophy; on the other hand, alterations in autophagy and lysosomal pathways are a common finding in essentially all diseases of the eye. Moreover, LC3-associated phagocytosis, a form of non-canonical autophagy, is critical in promoting visual cycle function. This review collects the latest understanding of autophagy in the context of the eye. We will review and discuss the respective roles of autophagy in the physiology and/or pathophysiology of each of the ocular tissues, its diurnal/circadian variation, as well as its involvement in diseases of the eye.
Details
- Title: Subtitle
- AUTOPHAGY IN THE EYE: FROM PHYSIOLOGY TO PATHOPHYSOLOGY
- Creators
- Paloma B Liton - Duke UniversityKathleen Boesze-Battaglia - University of PennsylvaniaMichael E Boulton - University of Alabama at BirminghamPatricia Boya - University of FribourgThomas A Ferguson - Washington University in St. LouisIan G Ganley - University of DundeeAnu Kauppinnen - University of Eastern FinlandGordon W Laurie - University of VirginiaNoboru Mizushima - The University of TokyoHideaki Morishita - The University of TokyoRossella Russo - University of CalabriaJaya Sadda - University of MichiganRajalekshmy Shyam - Indiana University BloomingtonDebasish Sinha - University of PittsburghDebra A Thompson - University of MichiganDavid N Zacks - University of Michigan
- Resource Type
- Journal article
- Publication Details
- Autophagy reports, Vol.2(1), 2178996
- DOI
- 10.1080/27694127.2023.2178996
- PMID
- 37034386
- PMCID
- PMC10078619
- NLM abbreviation
- Autophagy Rep
- ISSN
- 2769-4127
- eISSN
- 2769-4127
- Grant note
- R01 EY032956 / NEI NIH HHS R01 EY026885 / NEI NIH HHS R01 EY026171 / NEI NIH HHS K99 EY032974 / NEI NIH HHS R01 EY020823 / NEI NIH HHS P30 EY001583 / NEI NIH HHS R01 EY026525 / NEI NIH HHS R01 EY034160 / NEI NIH HHS R01 EY027733 / NEI NIH HHS R00 EY032974 / NEI NIH HHS
- Language
- English
- Date published
- 2023
- Academic Unit
- Anatomy and Cell Biology
- Record Identifier
- 9984949261402771
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