Journal article
AVIAN INFLUENZA VIRUS: THE NEXT PANDEMIC?
Transactions of the American Clinical and Climatological Association, Vol.135, pp.87-98
01/01/2025
PMCID: PMC12323483
PMID: 40771611
Abstract
Novel avian influenza viruses continue to circulate in animal species around the world and show a propensity to reassort and acquire virulence factors, which raises the concern that these viruses may adapt to humans. Pandemic preparedness has relied heavily on vaccine stockpiles. However, avian influenza strains genetically drift over time, and stockpiled vaccines often fail to elicit protective immunity for these genetic variants. Various strategies can help overcome immune imprinting and immunological hyporeactivity as well as broaden the immune response to variant viruses. Adjuvants remain a key strategy for improving the immunological response to avian influenza antigens. Today, three vaccines are approved in the United States for H5N1 influenza viruses though continued focus on surveillance and pandemic preparedness is essential to prepare for the possibility of human-to-human spread of this highly pathogenic influenza virus.
Details
- Title: Subtitle
- AVIAN INFLUENZA VIRUS: THE NEXT PANDEMIC?
- Creators
- Patricia L. Winokur - Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- Transactions of the American Clinical and Climatological Association, Vol.135, pp.87-98
- PMID
- 40771611
- PMCID
- PMC12323483
- NLM abbreviation
- Trans Am Clin Climatol Assoc
- ISSN
- 0065-7778
- Publisher
- American Clinical and Climatological Association
- Number of pages
- 12
- Language
- English
- Date published
- 01/01/2025
- Academic Unit
- Infectious Diseases; Medicine Administration; Internal Medicine
- Record Identifier
- 9984945082502771
Metrics
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