Abdominal vagal mediation of the satiety effects of CCK in rats

Roger D Reidelberger; Jessica Hernandez; Bernd Fritzsch; Martin Hulce

doi:10.1152/ajpregu.00646.2003

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Abdominal vagal mediation of the satiety effects of CCK in rats

Journal article

Peer reviewed

Abdominal vagal mediation of the satiety effects of CCK in rats

Roger D Reidelberger, Jessica Hernandez, Bernd Fritzsch and Martin Hulce

American journal of physiology. Regulatory, integrative and comparative physiology, Vol.286(6), pp.R1005-1012

06/2004

DOI: 10.1152/ajpregu.00646.2003

PMID: 14701717

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Abstract

CCK type 1 (CCK1) receptor antagonists differing in blood-brain barrier permeability were used to test the hypothesis that satiety is mediated in part by CCK action at CCK1 receptors on vagal sensory nerves innervating the small intestine. Devazepide penetrates the blood-brain barrier; A-70104, the dicyclohexylammonium salt of N alpha-3-quinolinoyl-D-Glu-N,N-dipentylamide, does not. At dark onset, non-food-deprived control rats and rats with subdiaphragmatic vagotomies received a bolus injection of devazepide (2.5 micromol/kg i.v.) or a 3-h infusion of A-70104 (3 micromol.kg(-1).h(-1) i.v.) either alone or coadministered with a 2-h intragastric infusion of peptone (0.75 or 1 g/h). Food intake was determined from continuous computer recordings of changes in food bowl weight. In control rats both antagonists stimulated food intake and attenuated the anorexic response to intragastric infusion of peptone. In contrast, only devazepide was effective in stimulating food intake in vagotomized rats. Thus endogenous CCK appears to act both at CCK1 receptors beyond the blood-brain barrier and by a CCK1 receptor-mediated mechanism involving abdominal vagal nerves to inhibit food intake.

Receptors, Cholecystokinin - antagonists & inhibitors

Sincalide - pharmacology

Male

Cholecystokinin - antagonists & inhibitors

Quinolines - administration & dosage

Abdomen - innervation

Quinolines - pharmacology

Eating - physiology

Receptors, Cholecystokinin - physiology

Satiety Response - physiology

Devazepide - pharmacology

Peptones - pharmacology

Cholecystokinin - physiology

Cholecystokinin - pharmacology

Rats

Sincalide - administration & dosage

Devazepide - administration & dosage

Rats, Sprague-Dawley

Vagotomy

Hormone Antagonists - administration & dosage

Hormone Antagonists - pharmacology

Eating - drug effects

Peptones - administration & dosage

Vagus Nerve - physiology

Animals

Infusions, Intravenous

Details

Title: Subtitle: Abdominal vagal mediation of the satiety effects of CCK in rats
Creators: Roger D Reidelberger - Department of Veterans Affairs-Nebraska Western Iowa Health Care System, and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA. Roger.Reidelberger@med.va.gov
Jessica Hernandez
Bernd Fritzsch
Martin Hulce
Resource Type: Journal article
Publication Details: American journal of physiology. Regulatory, integrative and comparative physiology, Vol.286(6), pp.R1005-1012
DOI: 10.1152/ajpregu.00646.2003
PMID: 14701717
NLM abbreviation: Am J Physiol Regul Integr Comp Physiol
ISSN: 0363-6119
eISSN: 1522-1490
Publisher: United States
Grant note: DK-52447 / NIDDK NIH HHS DK-55830 / NIDDK NIH HHS
Language: English
Date published: 06/2004
Academic Unit: Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
Record Identifier: 9984070732602771

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