Aberrant free radical biology is a unifying theme in the etiology and pathogenesis of major human diseases

Frederick E Domann

doi:10.3390/ijms14048491

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Aberrant free radical biology is a unifying theme in the etiology and pathogenesis of major human diseases

Journal article

Open access

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Aberrant free radical biology is a unifying theme in the etiology and pathogenesis of major human diseases

Frederick E Domann

International journal of molecular sciences, Vol.14(4), pp.8491-8495

04/17/2013

DOI: 10.3390/ijms14048491

PMCID: PMC3645757

PMID: 23594999

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Abstract

The seemingly disparate areas of oxygen toxicity, radiation exposure, and aging are now recognized to share a common feature-the aberrant production and/or removal of biologically derived free radicals and other reactive oxygen and nitrogen species (ROS/RNS). Advances in our understanding of the effects of free radicals in biology and medicine have been, and continue to be, actively translated into clinically tractable diagnostic and therapeutic applications. This issue is dedicated to recent advances, both basic discoveries and clinical applications, in the field of free radicals in biology and medicine. As more is understood about the proximal biological targets of aberrantly produced or removed reactive species, their sensors, and effectors of compensatory response, a great deal more will be learned about the commonalities in mechanisms underlying seemingly disparate disease states. Together with this deeper understanding, opportunities will arise to devise rational therapeutic interventions to decrease the incidence and severity of these diseases and positively impact the human healthspan.

Disease - etiology

Reactive Oxygen Species - metabolism

Oxidative Stress

Reactive Nitrogen Species - metabolism

Humans

Free Radicals - metabolism

Mitochondria - metabolism

Aging - metabolism

Details

Title: Subtitle: Aberrant free radical biology is a unifying theme in the etiology and pathogenesis of major human diseases
Creators: Frederick E Domann - Departments of Radiation Oncology, Surgery, and Pathology; Carver College of Medicine, the University of Iowa, Iowa City, IA 52242, USA. frederick-domann@uiowa.edu
Resource Type: Journal article
Publication Details: International journal of molecular sciences, Vol.14(4), pp.8491-8495
DOI: 10.3390/ijms14048491
PMID: 23594999
PMCID: PMC3645757
NLM abbreviation: Int J Mol Sci
ISSN: 1422-0067
eISSN: 1422-0067
Publisher: Switzerland
Grant note: P30 ES005605 / NIEHS NIH HHS
Language: English
Date published: 04/17/2013
Academic Unit: Pathology; Surgery; Radiation Oncology
Record Identifier: 9984047671202771

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