Journal article
Abiraterone in heavily pretreated patients with metastatic castrate-resistant prostate cancer
Anti-cancer drugs, Vol.25(4), pp.472-477
04/2014
DOI: 10.1097/CAD.0000000000000072
PMID: 24394473
Abstract
The aim of this study was to evaluate the activity and tolerability of abiraterone acetate in patients with metastatic castrate-resistant prostate cancer treated previously with more than three lines of chemotherapy. Patients received 1 g of abiraterone acetate (administered as four 250 mg tablets) orally once daily with prednisone at a dose of 5 mg orally twice daily. The primary endpoint was prostate-specific antigen (PSA) response. From August 2011 to January 2013, 36 patients were enrolled. PSA response was observed in 22 patients (61.1%, 95% confidence interval: 0.41-0.81). The median time to PSA progression was 7.3 months and after a median follow-up of 10.1 months, all patients were alive. The treatment was generally well tolerated; side effects secondary to mineralocorticoid excess resulting from blockade of CYP17 were largely controlled with prednisone. Abiraterone acetate seems to be an effective and well-tolerated treatment option for patients with metastatic castrate-resistant prostate cancer irrespective of the number of chemotherapy lines administered previously.
Details
- Title: Subtitle
- Abiraterone in heavily pretreated patients with metastatic castrate-resistant prostate cancer
- Creators
- Edoardo Francini - University of SienaAnna Ida Fiaschi - Brain Physiology LabRoberto Petrioli - University of SienaFilippo Francini - University of SienaVincenzo Bianco - Policlinico Umberto IArmando Perrella - University of SienaGiovanni Paganini - University of SienaLetizia Laera - University of SienaGiandomenico Roviello - University of Siena
- Resource Type
- Journal article
- Publication Details
- Anti-cancer drugs, Vol.25(4), pp.472-477
- DOI
- 10.1097/CAD.0000000000000072
- PMID
- 24394473
- NLM abbreviation
- Anticancer Drugs
- ISSN
- 0959-4973
- eISSN
- 1473-5741
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Language
- English
- Date published
- 04/2014
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985221143702771
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