Journal article
Ablation of stage T1/T2 prostate cancer with permanent interstitial temperature self-regulating rods
Journal of endourology, Vol.19(7), pp.865-867
2005
DOI: 10.1089/end.2005.19.865
PMID: 16190846
Abstract
Purpose: To determine if stage T1/T2 prostate cancer can be treated safely and effectively with interstitial thermal ablation.
Patients and Methods: Twenty patients with biopsy-confirmed prostate cancer were enrolled in the protocol. The average age was 71.0 years, and the pretreatment prostate specific antigen (PSA) concentration ranged from 2.5 to 10.7 ng/mL and the Gleason sum from 3 to 7. An array of small biocompatible magnetic alloy rods was placed in the patients percutaneously in a procedure analogous to the placement of brachytherapy seeds. Rods were placed end-to-end and no further than 1 cm apart; rods extended to the capsule and were placed at the capsule in the rectal grove. The rods are temperature self-regulating and heat to 70°C when placed in an alternating magnetic field. Each patient was treated in a coil system that supplies a uniform magnetic field throughout the patient's pelvis for a single 60-minute session. Urethral cooling and rectal temperature monitoring was performed. Serial PSA was followed, and biopsy was performed 1 year post-treatment.
Results: Immediately after treatment, most PSA values increased dramatically but then fell to <1.0 ng/mL within 8 weeks. After 1 year, five patients had positive biopsies; these patients had significantly lower rodimplant densities. Eight patients reported erectile dysfunction, but none reported incontinence. Other complications were minor.
Conclusion: The data suggest that this technique is well tolerated and safe and may be useful in certain patients with T1/T2 prostate cancer.
Details
- Title: Subtitle
- Ablation of stage T1/T2 prostate cancer with permanent interstitial temperature self-regulating rods
- Creators
- Robert D TUCKER - Department of Pathology, University of Iowa Hospitals, Iowa City, Iowa, United StatesChristian HUIDOBRO - Department of Urology, University of Chile, Santiago, ChileThayne LARSON - Institute of Medical Research, Scottsdale, Arizona, United States
- Resource Type
- Journal article
- Publication Details
- Journal of endourology, Vol.19(7), pp.865-867
- DOI
- 10.1089/end.2005.19.865
- PMID
- 16190846
- NLM abbreviation
- J Endourol
- ISSN
- 0892-7790
- eISSN
- 1557-900X
- Publisher
- Liebert; New York, NY
- Language
- English
- Date published
- 2005
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Pathology
- Record Identifier
- 9984047677802771
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