Abnormal 8-Hz flicker electroretinograms in carriers of X-linked retinoschisis

J Jason McAnany; Jason C Park; Frederick T Collison; Gerald A Fishman; Edwin M Stone

doi:10.1007/s10633-016-9551-0

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Abnormal 8-Hz flicker electroretinograms in carriers of X-linked retinoschisis

Journal article

Open access

Peer reviewed

Abnormal 8-Hz flicker electroretinograms in carriers of X-linked retinoschisis

J Jason McAnany, Jason C Park, Frederick T Collison, Gerald A Fishman and Edwin M Stone

Documenta ophthalmologica, Vol.133(1), pp.61-70

08/2016

DOI: 10.1007/s10633-016-9551-0

PMCID: PMC5556686

PMID: 27369766

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Abstract

To evaluate rod-isolated, cone-isolated, and combined rod and cone flicker electroretinograms (ERGs) as a possible means to identify electrophysiological abnormalities in carriers of X-linked retinoschisis (XLRS). Full-field ERGs were recorded from six carriers of XLRS (aged 34-66 years) and eight normally sighted subjects (aged 27-59 years) under rod-isolated (ERGR), cone-isolated (ERGC), and combined rod and cone (ERGR+C) conditions. ERGs were obtained using a four-primary LED-based ganzfeld photostimulator and standard recording techniques. The four primaries were modulated sinusoidally in phase to achieve combined rod and cone activation (ERGR+C) or in different phases to achieve ERGR and ERGC by means of triple silent substitution. After 30 min of dark adaptation, 8- and 15-Hz ERGR, ERGC, and ERGR+C responses were obtained at a mean luminance level of 24 scot. cd/m(2). Standard ISCEV ERGs were also obtained from each subject. The ISCEV and 15-Hz flicker ERGs were generally within the normal range for the carriers. The 8-Hz ERGR, ERGC, and ERGR+C amplitudes were also generally normal. In contrast, the carriers had ERGR, ERGC, and ERGR+C timing abnormalities, with phase advances beyond the range of normal for the ERGR (four carriers), ERGC (four carriers), and ERGR+C (three carriers). Only one carrier had normal 8-Hz responses under all conditions. The 8-Hz ERG timing abnormalities in five of six carriers indicate that retinal function is not necessarily normal in carriers of XLRS. The 8-Hz flicker ERG may be useful for studying retinal function in these individuals.

Electroretinography - methods

Humans

Middle Aged

Retinal Cone Photoreceptor Cells - physiology

Dark Adaptation - physiology

Male

Retina

Case-Control Studies

Flicker Fusion - physiology

Retinoschisis - physiopathology

Vision, Ocular - physiology

Photic Stimulation - methods

Retinal Rod Photoreceptor Cells - physiology

Adult

Female

Aged

Details

Title: Subtitle: Abnormal 8-Hz flicker electroretinograms in carriers of X-linked retinoschisis
Creators: J Jason McAnany - Department of Bioengineering, University of Illinois at Chicago, 851 South Morgan St., Chicago, IL, 60607, USA. jmcana1@uic.edu
Jason C Park - Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 W. Taylor St., Chicago, IL, 60612, USA
Frederick T Collison - The Pangere Center for Inherited Retinal Diseases, The Chicago Lighthouse, Chicago, IL, USA
Gerald A Fishman - The Pangere Center for Inherited Retinal Diseases, The Chicago Lighthouse, Chicago, IL, USA
Edwin M Stone - Stephen A. Wynn Institute for Vision Research, Department Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Documenta ophthalmologica, Vol.133(1), pp.61-70
DOI: 10.1007/s10633-016-9551-0
PMID: 27369766
PMCID: PMC5556686
NLM abbreviation: Doc Ophthalmol
ISSN: 0012-4486
eISSN: 1573-2622
Publisher: Netherlands
Grant note: P30 EY001792 / NEI NIH HHS R00 EY019510 / NEI NIH HHS
Language: English
Date published: 08/2016
Academic Unit: Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983980063302771

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