Journal article
Abnormal Brain Morphology in Patients With Isolated Cleft Lip, Cleft Palate, or Both: A Preliminary Analysis
The Cleft palate-craniofacial journal, Vol.37(5), pp.441-446
09/2000
DOI: 10.1597/1545-1569_2000_037_0441_abmipw_2.0.co_2
PMID: 11034025
Abstract
Objective: The aim of this study was to determine whether adult men with cleft lip and palate (CLP) have aberrant cerebral morphology.
Design: Brain morphology of 14 adult men with isolated CLP were analyzed and compared with 14 healthy controls matched for sex, age, and parental socioeconomic status.
Setting: The research took place at a large, tertiary care hospital, with participation on an outpatient basis.
Participants: The 14 males with CLP were recruited from a large cleft lip and palate registry, while their 14 matched controls were selected from a registry of healthy volunteers collected via the Mental Health Clinical Research Center.
Results: The males with CLP have significantly smaller cerebellar size (p = .04), significantly larger frontal lobes (p = .02), and significantly smaller temporal and occipital lobes (p = .02; p = .009, respectively). No significant difference in gray/white matter ratios or laterality were found.
Conclusions: Adult males with CLP have a significantly different pattern of brain morphology, compared with healthy controls, which is most likely due to aberrant cerebral development. This study highlights the complex interaction and interdependence of craniofacial and cerebral development.
Details
- Title: Subtitle
- Abnormal Brain Morphology in Patients With Isolated Cleft Lip, Cleft Palate, or Both: A Preliminary Analysis
- Creators
- Peg NopoulosStephanie BergJohn CanadyLynn RichmanDuane Van DemarkNancy C Andreasen
- Resource Type
- Journal article
- Publication Details
- The Cleft palate-craniofacial journal, Vol.37(5), pp.441-446
- DOI
- 10.1597/1545-1569_2000_037_0441_abmipw_2.0.co_2
- PMID
- 11034025
- ISSN
- 1055-6656
- eISSN
- 1545-1569
- Language
- English
- Date published
- 09/2000
- Academic Unit
- Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology
- Record Identifier
- 9984003943002771
Metrics
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