Journal article
Abnormal Glucose Tolerance in Infants and Young Children with Cystic Fibrosis
American journal of respiratory and critical care medicine, Vol.194(8), pp.974-980
10/15/2016
DOI: 10.1164/rccm.201512-2518OC
PMCID: PMC5067820
PMID: 27447840
Abstract
In cystic fibrosis, abnormal glucose tolerance is associated with decreased lung function and worsened outcomes. Translational evidence indicates that abnormal glucose tolerance may begin in early life.
To determine whether very young children with cystic fibrosis have increased abnormal glucose tolerance prevalence compared with control subjects. The secondary objective was to compare area under the curve for glucose and insulin in children with cystic fibrosis with control subjects.
This is a prospective multicenter study in children ages 3 months to 5 years with and without cystic fibrosis.
Oral glucose tolerance testing with glucose, insulin, and C-peptide was sampled at 0, 10, 30, 60, 90, and 120 minutes. Twenty-three children with cystic fibrosis and nine control subjects had complete data. All control subjects had normal glucose tolerance. Nine of 23 subjects with cystic fibrosis had abnormal glucose tolerance (39%; P = 0.03). Of those, two met criteria for cystic fibrosis-related diabetes, two indeterminate glycemia, and six impaired glucose tolerance. Children with cystic fibrosis failed to exhibit the normal increase in area under the curve insulin with age observed in control subjects (P < 0.01), despite increased area under the curve glucose (P = 0.02).
Abnormal glucose tolerance is notably prevalent among young children with cystic fibrosis. Children with cystic fibrosis lack the normal increase in insulin secretion that occurs in early childhood despite increased glucose. These findings demonstrate that glycemic abnormalities begin very early in cystic fibrosis, possibly because of insufficient insulin secretion.
Details
- Title: Subtitle
- Abnormal Glucose Tolerance in Infants and Young Children with Cystic Fibrosis
- Creators
- Yaling Yi - 1 Department of Anatomy and Cell BiologyAndrew W Norris - 3 Fraternal Order of Eagles Diabetes Research Center, andKai Wang - 4 Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa; andXingshen Sun - 1 Department of Anatomy and Cell BiologyAliye Uc - 2 Department of PediatricsAntoinette Moran - 5 Department of Pediatrics, University of Minnesota, Minneapolis, MinnesotaJohn F Engelhardt - 3 Fraternal Order of Eagles Diabetes Research Center, andKatie Larson Ode - 3 Fraternal Order of Eagles Diabetes Research Center, and
- Resource Type
- Journal article
- Publication Details
- American journal of respiratory and critical care medicine, Vol.194(8), pp.974-980
- DOI
- 10.1164/rccm.201512-2518OC
- PMID
- 27447840
- PMCID
- PMC5067820
- NLM abbreviation
- Am J Respir Crit Care Med
- ISSN
- 1073-449X
- eISSN
- 1535-4970
- Publisher
- United States
- Grant note
- R01 DK097820 / NIDDK NIH HHS U54 TR001356 / NCATS NIH HHS R24 DK096518 / NIDDK NIH HHS UL1 TR000114 / NCATS NIH HHS U01 DK108334 / NIDDK NIH HHS P30 DK054759 / NIDDK NIH HHS
- Language
- English
- Date published
- 10/15/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Endocrinology and Diabetes; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Biostatistics; Radiation Oncology; Gastroenterology, Hepatology, Pancreatology, and Nutrition; Biochemistry and Molecular Biology; Internal Medicine
- Record Identifier
- 9983997366502771
Metrics
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