Journal article
Abnormal Vascular Responses to Exercise in Patients with Aortic Stenosis
The Journal of clinical investigation, Vol.52(5), pp.1138-1146
05/1973
DOI: 10.1172/JCI107280
PMCID: PMC302369
PMID: 4700489
Abstract
We tested the hypothesis that the normal forearm vasoconstrictor response to leg exercise is inhibited or reversed in patients with aortic stenosis, possibly because of activation of left ventricular baroreceptors. Forearm vascular responses to supine leg exercise were measured in 10 patients with aortic stenosis and in 2 control groups of 6 patients with mitral stenosis and 5 patients without valvular heart disease.\nForearm vasoconstriction occurred during exercise in the control groups. In contrast, forearm blood flow increased and forearm vascular resistance did not change in patients with aortic stenosis. In six patients with aortic stenosis and a history of exertional syncope, forearm vasodilatation occurred during the second minute of leg exercise. Inhibition or reversal of forearm vasoconstrictor responses in aortic stenosis was asscociated with significant increases in left ventricular pressure.\nIn three patients with aortic stenosis and exertional syncope, forearm vasodilator responses to exercise changed to vasoconstrictor responses after aortic valve replacement.\nThe results indicate that forearm vasoconstrictor responses to leg exercise are inhibited or reversed in patients with aortic stenosis, possibly because of activation of left ventricular baroreceptors. The observations suggest that reflex vasodilatation resulting from activation of left ventricular baroreceptors may contribute to exertional syncope in patients with aortic stenosis.
Details
- Title: Subtitle
- Abnormal Vascular Responses to Exercise in Patients with Aortic Stenosis
- Creators
- Allyn L Mark - Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine and the Veterans Administration Hospital, Iowa City, Iowa 52240J. Michael Kioschos - Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine and the Veterans Administration Hospital, Iowa City, Iowa 52240Francois M Abboud - Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine and the Veterans Administration Hospital, Iowa City, Iowa 52240Donald D Heistad - Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine and the Veterans Administration Hospital, Iowa City, Iowa 52240Phillip G Schmid - Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine and the Veterans Administration Hospital, Iowa City, Iowa 52240
- Resource Type
- Journal article
- Publication Details
- The Journal of clinical investigation, Vol.52(5), pp.1138-1146
- Publisher
- American Society for Clinical Investigation
- DOI
- 10.1172/JCI107280
- PMID
- 4700489
- PMCID
- PMC302369
- ISSN
- 0021-9738
- eISSN
- 1558-8238
- Language
- English
- Date published
- 05/1973
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984025480302771
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