Journal article
Abnormal Ventilatory Responses in Adults Born Prematurely
The New England journal of medicine, Vol.370(6), pp.584-585
02/06/2014
DOI: 10.1056/NEJMc1311092
PMCID: PMC4769592
PMID: 24499235
Abstract
Investigators examined adults who had been exposed to perinatal hyperoxia as infants and report that such people may have diminished hypoxic and hyperoxic ventilatory responses.
To the Editor:
Perinatal hyperoxia in preterm infants is associated with several well-known sequelae, including bronchopulmonary dysplasia and retinopathy of prematurity. Hyperoxia also induces alterations in cardiopulmonary control (e.g., preterm infants treated with hyperoxia lack normal ventilatory responses to hypoxia and hyperoxia).
1
,
2
It has not been determined whether these impairments diminish with age. Thus, we sought to determine whether or not ventilatory dysfunction persists in adults who were born prematurely.
We measured the ventilatory responses to 5 minutes of isocapnic, isobaric hypoxia (in which the fraction of inspired oxygen [FiO
2
] was 0.12) and hyperoxia (in which the . . .
Details
- Title: Subtitle
- Abnormal Ventilatory Responses in Adults Born Prematurely
- Creators
- Melissa L Bates - University of Wisconsin–MadisonEmily T Farrell - University of Wisconsin School of Medicine and Public HealthMarlowe W Eldridge - University of Wisconsin School of Medicine and Public Health
- Resource Type
- Journal article
- Publication Details
- The New England journal of medicine, Vol.370(6), pp.584-585
- Publisher
- Massachusetts Medical Society
- DOI
- 10.1056/NEJMc1311092
- PMID
- 24499235
- PMCID
- PMC4769592
- ISSN
- 0028-4793
- eISSN
- 1533-4406
- Language
- English
- Date published
- 02/06/2014
- Academic Unit
- Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984259391802771
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