Journal article
Abnormal coronary function in mice deficient in α1H T-type Ca2+ channels
Science (American Association for the Advancement of Science), Vol.302(5649), pp.1416-1418
2003
DOI: 10.1126/science.1089268
Abstract
Calcium ion (Ca2+) influx through voltage-gated Ca2+ channels is important for the regulation of vascular tone. Activation of L-type Ca2+ channels initiates muscle contraction; however, the role of T-type Ca2+ channels (T-channels) is not clear. We show that mice deficient in the alpha1H T-type Ca2+ channel (alpha(1)3.2-null) have constitutively constricted coronary arterioles and focal myocardial fibrosis. Coronary arteries isolated from alpha(1)3.2-null arteries showed normal contractile responses, but reduced relaxation in response to acetylcholine and nitroprusside. Furthermore, acute blockade of T-channels with Ni2+ prevented relaxation of wild-type coronary arteries. Thus, Ca2+ influx through alpha1H T-type Ca2+ channels is essential for normal relaxation of coronary arteries.
Details
- Title: Subtitle
- Abnormal coronary function in mice deficient in α1H T-type Ca2+ channels
- Creators
- Chien-Chang CHEN - Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, United StatesKathryn G LAMPING - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, United StatesRoger A WILLIAMSON - Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA 52242, United StatesJoseph A HILL - Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, United StatesKevin P CAMPBELL - Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, United StatesDaniel W NUNO - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, United StatesRita BARRESI - Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, United StatesSally J PROUTY - Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, United StatesJulie L LAVOIE - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, United StatesLeanne L CRIBBS - Cardiovascular Institute, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, United StatesSarah K ENGLAND - Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, United StatesCurt D SIGMUND - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, United StatesRobert M WEISS - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.302(5649), pp.1416-1418
- Publisher
- American Association for the Advancement of Science; Washington, DC
- DOI
- 10.1126/science.1089268
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Language
- English
- Date published
- 2003
- Academic Unit
- Molecular Physiology and Biophysics; Neuroscience and Pharmacology; Cardiovascular Medicine; Obstetrics and Gynecology; Internal Medicine; Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984020994502771
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