Journal article
Abnormal escape from dexamethasone suppression in agoraphobia with panic attacks
Psychiatry research, Vol.15(4), pp.301-311
1985
DOI: 10.1016/0165-1781(85)90067-8
PMID: 2866558
Abstract
Patients who met
DSM-III criteria for agoraphobia with panic attacks underwent dexamethasone suppression tests (DSTs) before, during, and after treatment with alprazolam or placebo. Similarly, outpatients with major depression were given multiple DSTs as they participated in a study of desmethylimipramine efficacy. The likelihood of an abnormal escape from dexamethasone was similar in the two diagnostic groups; nonsuppression was somewhat more likely among patients with primary depression, but comparisons with agoraphobic groups remained statistically insignificant. These results apparently did not reflect misclassification of primary depression patients as agoraphobics since a history of major depression was not related to the likelihood of nonsuppression within that group. Moreover, change in DST results during treatment reflected clinical change among agoraphobics. After a review of relevant followup and family studies, we conclude that panic disorder and primary depression are separate illnesses and that hypothalamic-pituitary-adrenal axis hyperactivity is an epiphenomenon of both.
Details
- Title: Subtitle
- Abnormal escape from dexamethasone suppression in agoraphobia with panic attacks
- Creators
- William Coryell - William Corynell, M.D., is Associate Professor of Psychiatry, University of Iowa College of Medicine, Department of Psychiatry, 500 Newton Rd., Iowa City, IA 52242, USARussell Noyes - Russell Noyes, Jr., M.D., University of Iowa College of Medicine, Department of Psychiatry, 500 Newton Rd., Iowa City, IA 52242, USAJohn Clancy - John Clancy, M.D., is a Professor of Psychiatry, University of Iowa College of Medicine, Department of Psychiatry, 500 Newton Rd., Iowa City, IA 52242, USARaymond Crowe - Raymond Crowe, M.D., is a Professor of Psychiatry, University of Iowa College of Medicine, Department of Psychiatry, 500 Newton Rd., Iowa City, IA 52242, USADewat Chaudhry - Dewat Chaudhry, M.D., is in private practice, USA
- Resource Type
- Journal article
- Publication Details
- Psychiatry research, Vol.15(4), pp.301-311
- Publisher
- Elsevier Ireland Ltd
- DOI
- 10.1016/0165-1781(85)90067-8
- PMID
- 2866558
- ISSN
- 0165-1781
- eISSN
- 1872-7123
- Language
- English
- Date published
- 1985
- Academic Unit
- Psychiatry
- Record Identifier
- 9984004187702771
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