Journal article
Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6)
Nature genetics, Vol.38(11), pp.1335-1340
0
11/2006
DOI: 10.1038/ng1903
PMCID: PMC2082114
PMID: 17041601
Abstract
Transcription factor paralogs may share a common role in staged or overlapping expression in specific tissues, as in the Hox family. In other cases, family members have distinct roles in a range of embryologic, differentiation or response pathways (as in the Tbx and Pax families). For the interferon regulatory factor (IRF) family of transcription factors, mice deficient in Irf1, Irf2, Irf3, Irf4, Irf5, Irf7, Irf8 or Irf9 have defects in the immune response but show no embryologic abnormalities. Mice deficient for Irf6 have not been reported, but in humans, mutations in IRF6 cause two mendelian orofacial clefting syndromes, and genetic variation in IRF6 confers risk for isolated cleft lip and palate. Here we report that mice deficient for Irf6 have abnormal skin, limb and craniofacial development. Histological and gene expression analyses indicate that the primary defect is in keratinocyte differentiation and proliferation. This study describes a new role for an IRF family member in epidermal development.
Details
- Title: Subtitle
- Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6)
- Creators
- Christopher R. IngrahamAkira KinoshitaShinji KondoBaoli Yang - University of IowaSamin SajanKurt J. TroutMargaret I. MalikMartine DunnwaldStephen L. GoudyMichael LovettJeffrey C. MurrayBrian C. Schutte
- Resource Type
- Journal article
- Publication Details
- Nature genetics, Vol.38(11), pp.1335-1340
- Event
- 0
- DOI
- 10.1038/ng1903
- PMID
- 17041601
- PMCID
- PMC2082114
- NLM abbreviation
- Nat Genet
- ISSN
- 1061-4036
- eISSN
- 1546-1718
- Publisher
- Nature Publishing Group; New York
- Language
- English
- Date published
- 11/2006
- Academic Unit
- Anatomy and Cell Biology; Craniofacial Anomalies Research Center; BioVentures Center; Obstetrics and Gynecology
- Record Identifier
- 9983557492802771
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