Journal article
Abnormalities in midline attentional circuitry in schizophrenia: evidence from magnetic resonance and positron emission tomography
European neuropsychopharmacology, Vol.5(1), pp.37-41
1995
DOI: 10.1016/0924-977X(95)00028-N
PMID: 8775757
Abstract
The syndrome of schizophrenia presents with a complex array of symptoms that are difficult to explain at the neural level. Data collected using magnetic resonance (MR) and positron emission tomography (PET) suggest that this complex array could occur as a consequence of misconnections and mismatches in midline circuitry that is reticular-thalamic-cingulate-cortical. MR studies have shown a variety of abnormalities, including callosal agenesis, cavum septi pellucidi, decreased thalamic size, decreased frontal size, and changes in signal intensity in white matter tracts between the thalamus and the frontal cortex. PET studies using a dichotic listening paradigm suggest that patients suffering from schizophrenia have brain blood flow abnormalities consistent with a difficulty in focusing or shifting attention, which may reflect the functional substrate of the anatomic abnormalities.
Details
- Title: Subtitle
- Abnormalities in midline attentional circuitry in schizophrenia: evidence from magnetic resonance and positron emission tomography
- Creators
- Nancy C Andreasen - The Mental Health Clinical Research Center, The University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USAVictor Swayze - The Mental Health Clinical Research Center, The University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USADaniel S O'Leary - The Mental Health Clinical Research Center, The University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USAPeg Nopoulos - The Mental Health Clinical Research Center, The University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USATed Cizadlo - The Mental Health Clinical Research Center, The University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USAGreg Harris - The Mental Health Clinical Research Center, The University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USAStephan Arndt - The Mental Health Clinical Research Center, The University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USAMichael Flauma - The Mental Health Clinical Research Center, The University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- European neuropsychopharmacology, Vol.5(1), pp.37-41
- DOI
- 10.1016/0924-977X(95)00028-N
- PMID
- 8775757
- NLM abbreviation
- Eur Neuropsychopharmacol
- ISSN
- 0924-977X
- eISSN
- 1873-7862
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 1995
- Academic Unit
- Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Biostatistics; Nursing; Injury Prevention Research Center
- Record Identifier
- 9984004090402771
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